Formaldehyde Publisher



Farhadi R^{1, 2} ; Bayrami Z^{1, 2}
Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023

Abstract

Formaldehyde is a very unstable chemical that is used widely in different industries, anatomy and research laboratories, and even in dentistry. Chronic occupational exposure resulting from formaldehyde fume in work circumstances is one of the most important toxicity routes. Immunotoxicity, genotoxicity, and carcinogenicity of formaldehyde have been studied as well as toxic effects on pulmonary, liver, kidney, skin, and nervous system. Acute toxicity of formaldehyde has serious symptoms such as fatal gastrointestinal ulcers and necrosis. LD50 of formaldehyde taken orally in rats and human is about 500mg/kg and it is almost fatal within 2 days. According to some guidelines, the formaldehyde level for indoor places is 100ppb and for occupational environments, is approximately 1000ppb whereas the WHO guideline sets a standard of 82ppb. © 2024 Elsevier Inc. All rights reserved.