Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
White Matter Changes Correlates of Peripheral Neuroinflammation in Patients With Parkinson's Disease Publisher Pubmed



Haghshomar M1, 2 ; Rahmani F1, 2 ; Hadi Aarabi M1, 2 ; Shahjouei S1, 3 ; Sobhani S1, 2 ; Rahmani M1, 4
Authors

Source: Neuroscience Published:2019


Abstract

Neuroinflammatory pathology has long been identified to contribute to the pathology of Parkinson disease. Early microstructural changes in white matter tracts might give a clue for earlier detection of PD. We investigated through diffusion MRI connectometry the structural correlates of white matter tracts of 81 patients with PD with whole blood neutrophil-to-lymphocyte ratio (NLR), controlling for age and sex. Diffusion data were reconstructed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function. The spin distribution function (SDF) values were used in DMRI connectometry analysis. The connectometry analyses identified white matter QA of the following fibers to be correlated with NLR score after adjustment for age and sex: bilateral cingulum, body and left crus of fornix, bilateral corticospinal tract (CST), and body and splenium of corpus callosum (CC) and superior cerebellar peduncle with decreased connectivity related to NLR (FDR = 0.04542). Keeping with emerging evidence on the role of neuroinflammation in PD pathology, these results with functional relevance to prodromal Parkinson disease, bring new insights to pivotal role of peripheral inflammation in CNS neurodegeneration. © 2017 IBRO
Other Related Docs
12. Differences in White Matter Microstructure Between Parkinson's Disease Patients With and Without Rem Sleep Behavior Disorder, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society# EMBS (2016)