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Tissue Composition Effect on Dose Distribution in Neutron Brachytherapy/Neutron Capture Therapy Publisher



Khosroabadi M1 ; Farhood B2 ; Ghorbani M3 ; Hamzian N3 ; Moghaddam HR1 ; Davenport D4
Authors

Source: Reports of Practical Oncology and Radiotherapy Published:2016


Abstract

Aim: The aim of this study is to assess the effect of the compositions of various soft tissues and tissue-equivalent materials on dose distribution in neutron brachytherapy/neutron capture therapy. Background: Neutron brachytherapy and neutron capture therapy are two common radiotherapy modalities. Materials and methods: Dose distributions were calculated around a low dose rate 252Cf source located in a spherical phantom with radius of 20.0cm using the MCNPX code for seven soft tissues and three tissue-equivalent materials. Relative total dose rate, relative neutron dose rate, total dose rate, and neutron dose rate were calculated for each material. These values were determined at various radial distances ranging from 0.3 to 15.0cm from the source. Results: Among the soft tissues and tissue-equivalent materials studied, adipose tissue and plexiglass demonstrated the greatest differences for total dose rate compared to 9-component soft tissue. The difference in dose rate with respect to 9-component soft tissue varied with compositions of the materials and the radial distance from the source. Furthermore, the total dose rate in water was different from that in 9-component soft tissue. Conclusion: Taking the same composition for various soft tissues and tissue-equivalent media can lead to error in treatment planning in neutron brachytherapy/neutron capture therapy. Since the International Commission on Radiation Units and Measurements (ICRU) recommends that the total dosimetric uncertainty in dose delivery in radiotherapy should be within ±5%, the compositions of various soft tissues and tissue-equivalent materials should be considered in dose calculation and treatment planning in neutron brachytherapy/neutron capture therapy. © 2015 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o.
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