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The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients Publisher Pubmed



Azizi Tabesh G1 ; Izadi P1 ; Fereidooni F2 ; Emami Razavi AN2 ; Tavakkoly Bazzaz J1
Authors

Source: Cancer Investigation Published:2017


Abstract

In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2– tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors. In our study, PIK3CA mutations were related to good and moderate prognosis in breast cancer patients. © 2017 Taylor & Francis Group, LLC.
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