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Photodisinfection Effects of Silver Sulfadiazine Nanoliposomes Doped-Curcumin on Acinetobacter Baumannii: A Mouse Model Publisher Pubmed



Pourhajibagher M1 ; Partoazar A2 ; Alaeddini M1 ; Etemadmoghadam S1 ; Bahador A3
Authors

Source: Nanomedicine Published:2020


Abstract

Aim: To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on Acinetobacter baumannii. Materials & methods: Following characterization, the cytotoxic and hemolytic activities of AgSD-NLs@Cur were evaluated. The antimicrobial activities of AgSD-NLs@Cur-mediated antimicrobial photodynamic therapy (aPDT) were determined. Histopathological examination of the burn wound sites of infected mice treated with photoexcited AgSD-NLs@Cur was assessed. Results: No significant cytotoxic and hemolytic activities were observed. There was a decrease in the Acinetobacter baumannii count in planktonic and biofilm forms and the gene expression level using AgSD-NLs@Cur-aPDT (p < 0.05). Histopathological analysis indicated the epidermis developed markedly and the bacterial load decreased significantly after aPDT. Conclusion: Photoexcited AgSD-NLs@Cur has an antimicrobial potential against A. baumannii. © 2020 Future Medicine Ltd.
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