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Synthesis and Biological Evaluation of Chalcone-Triazole Hybrid Derivatives As 15-Lox Inhibitors Publisher



Asadipour A2 ; Noushini S3 ; Moghimi S3 ; Mahdavi M4 ; Nadri H5 ; Moradi A5 ; Shabani S3 ; Firoozpour L3 ; Foroumadi A1, 2
Authors

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2018


Abstract

An efficient aldol condensation/click reaction sequence is employed for the synthesis of chalcone-triazole-based derivatives in moderate to good yields. The ability of target compounds to inhibit 15-lipoxygenase enzyme was investigated and moderate to low inhibitory activities were observed for the synthesized compounds. © 2018 Walter de Gruyter GmbH, Berlin/Boston.
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