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Role of Resveratrol in the Prevention and Treatment of Urological Cancers: New Perspectives on Multiple Molecular Targets and Signaling Pathways Publisher



Sam Hosseini Sayed Amir MOHAMMAD ; E Alaei ELMIRA ; Sm Doodmani Seyed MOHAMMAD ; P Rahimzadeh PAYMAN ; N Farahani NAJMA ; Ma Alimohammadi Mina AMIN ; S Daneshi S ; N Shafiee NADIA ; A Taheriazam AFSHIN ; M Mohammadi MAHYA
Authors

Source: Journal of Functional Foods Published:2025


Abstract

Resveratrol, a natural polyphenol with strong antioxidant and anti-inflammatory characteristics, has many beneficial effects on urological malignancies by targeting important signaling pathways. Resveratrol reduces metastasis in prostate cancer by downregulating MMP-9 and VEGF, causes apoptosis through Bcl-2 suppression and caspase-3/9 activation, and lowers androgen receptor (AR) signaling. Resveratrol also targets bladder cancer by disrupting stromal-tumor interactions, reducing HIF-1α-driven angiogenesis under hypoxia, and sensitizing cisplatin-resistant cells by influencing P-glycoprotein efflux. Resveratrol inhibits the VEGF and mTOR pathways in renal cell carcinoma, decreasing tumor growth and invasion. Notably, experimental findings indicated that resveratrol works synergistically with docetaxel and paclitaxel to improve chemotherapeutic effectiveness while decreasing drug resistance. Resveratrol activates SIRT1, inhibits NF-κB-mediated inflammation, and enhances autophagy via the Akt/mTOR axis, contributing to anticancer action through metabolic and epigenetic regulation. The present article highlights resveratrol's target molecules, emphasizes its efficacy as an adjuvant treatment, and suggests optimal delivery systems and biomarker-driven research to address the gap between molecular potential and clinical relevance. © 2025 Elsevier B.V., All rights reserved.
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