Quercetin and Glioma: Which Signaling Pathways Are Involved? Publisher Pubmed



Tamtaji OR^{1, 6} ; Razavi ZS² ; Razzaghi N³ ; Aschner M⁴ ; Barati E⁵ ; Mirzaei H¹
Source: Current Molecular Pharmacology Published:2022

Abstract

Gliomas are the most common brain tumors. These tumors commonly exhibit continuous growth without invading surrounding brain tissues. Dominant remedial approaches suffer limited therapy and survival rates. Although some progress has been made in conventional glioma treatments, these breakthroughs have not yet proven sufficient for treating this malignancy. The remedial options are limited given gliomas' aggressive metastasis and drug resistance. Quercetin, a flavonoid, is an anti-oxidative, anti-allergic, antiviral, anti-inflammatory, and anticancer compound. Multiple lines of evidence have shown that Quercetin has anti-tumor effects, documenting this natural compound exerts its pharmacological effects by targeting a variety of cellular and molecular processes, i.e., apoptosis, metastasis, and autophagy. Herein, we summarize various cellular and molecular pathways that are affected by Quercetin in gliomas. © 2022 Bentham Science Publishers.