Influence of Modafinil on Early Ejaculation – Results From a Double-Blind Randomized Clinical Trial Publisher Pubmed



Haghighi M¹ ; Jahangard L¹ ; Meybodi AM² ; Shayganfard M³ ; Ahmadpanah M¹ ; Faryadres M⁴ ; Dursteler KM^{5, 6} ; Bruhl AB⁷ ; Sadeghibahmani D^{7, 8, 9} ; Brand S^{7, 9, 10, 11, 12}
Source: Journal of Psychiatric Research Published:2022

Abstract

Background: For men, early ejaculation is a serious health concern. Here, we tested the influence of modafinil (Profinil®) on early ejaculation. To this end, we performed a double-blind randomized clinical trial among men with early ejaculation. Methods: A total of 46 men with early ejaculation (mean age: 37.35 years) and in stable marital relationships with regular weekly penile-vaginal intercourse were randomly assigned either to the modafinil (100 mg) or to the placebo condition. Compounds were taken about 4–6h before intended penile-vaginal intercourse. At baseline and four weeks later at the end of the study, participants completed a series of self-rating questionnaires covering early ejaculation. Female partners also rated their male partners’ early ejaculation profile. Results: Dimensions of early ejaculation improved over time, but only so in the modafinil condition, while no improvements were observed in the placebo condition. Conclusions: Among male adults in stable marital relationships with regular weekly penile-vaginal intercourse modafinil improved dimensions of early ejaculation, always compared to placebo. Given the strong effect of modafinil on cognitive-executive processes, it is conceivable, that modafinil acted both via physiological and cognitive-executive pathways. © 2021 Elsevier Ltd