Oxygen-Rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction Publisher Pubmed



Montazeri L¹ ; Kowsariesfahan R¹ ; Pahlavan S² ; Sobat M³ ; Rabbani S⁴ ; Ansari H² ; Varzideh F² ; Barekat M² ; Rajabi S¹ ; Navaee F⁵ ; Bonakdar S⁶ ; Renaud P⁵ ; Braun T⁷ ; Baharvand H^{2, 8}
Source: Materials Science and Engineering C Published:2021

Abstract

To some extent, cell therapy for myocardial infarction (MI) has supported the idea of cardiac repair; however, further optimizations are inevitable. Combined approaches that comprise suitable cell sources and supporting molecules considerably improved its effect. Here, we devised a strategy of simultaneous transplantation of human cardiac progenitor cells (CPCs) and an optimized oxygen generating microparticles (MPs) embedded in fibrin hydrogel, which was injected into a left anterior descending artery (LAD) ligating-based rat model of acute myocardial infarction (AMI). Functional parameters of the heart, particularly left ventricular systolic function, markedly improved and reached pre-AMI levels. This functional restoration was well correlated with substantially lower fibrotic tissue formation and greater vascular density in the infarct area. Our novel approach promoted CPCs retention and differentiation into cardiovascular lineages. We propose this novel co-transplantation strategy for more efficient cell therapy of AMI which may function by providing an oxygen-rich microenvironment, and thus regulate cell survival and differentiation. © 2020 Elsevier B.V.