Hyoscine Versus Diazepam for the Management of True Vertigo in the Emergency Department Publisher



Kariman H¹ ; Vajihi F¹ ; Amini A¹ ; Shahrami A¹ ; Arhamidolatabadi A¹ ; Shojaee M¹ ; Baratloo A²
Source: Bangladesh Journal of Pharmacology Published:2017

Abstract

The present study was a double-blind clinical trial to compare the efficiency of hysocine and diazepam in vertigo treatment. Eligible patients (n=69) were randomly divided into 2 groups of 5 mg hyoscine and 10 mg diazepam. Severity of vertigo was measured in supine and sitting position, and while turning the head. Vertigo severity was assessed before, and 1 and 2 hours after administration of the drug. Treatment success rate of diazepam in relieving vertigo in different positions varied between 88.9 and 100%, while this rate was 31.2–73.5% in hyoscine treatment group (p<0.01). Prescription of diazepam led to complete relief of vertigo in 40–63% of the patients, while this rate was only 2.6–12.5% in hyoscine treatment group (p<0.001). It is likely that diazepam is a better option than hyoscine for management of true vertigo in patients presenting to the emergency department. © 2017, Bangladesh Pharmacological Society. All rights reserved.