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Metal-Free Chemo- and Regioselective Acylation of Pyridine Derivatives With Alcohols in Water Publisher



Kianmehr E1 ; Pakbaznia A1 ; Faghih N1 ; Foroumadi A2
Authors

Source: Tetrahedron Published:2017


Abstract

A straightforward acylaltion of pyridine derivatives has been developed using K2S2O8as the oxidant and water as a green solvent. The corresponding 2-acylpyridines were synthesized with high chemo- and regioselectivity in good to high yields. This efficient and practical method could serve as a new tool for the convenient synthesis of 2-benzoylpyridines of interest for future pharmaceutical and chemical applications. © 2017 Elsevier Ltd