Comparison of Radiation and Chemoradiation-Induced Sensorineural Hearing Loss in Head and Neck Cancer Patients Publisher Pubmed



Mahdavi S^{1, 2} ; Rezaeyan A² ; Nikoofar A³ ; Bakhshandeh M⁴ ; Farahani S⁵ ; Cheraghi S^{1, 6}
Source: Journal of Cancer Research and Therapeutics Published:2020

Abstract

Aim: The purpose of this study was to assess and compare the incidence and severity of sensorineural hearing loss (SNHL) in head-and-neck patients undergoing radiotherapy (RT) and concurrent cisplatin-based chemoradiotherapy (CRT). Materials and Methods: Pure tone audiometry (PTA) was performed at 0.25-12 kHz on 35 RT and 25 CRT patients after 12-month followed up. The hearing loss was evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) criteria. Results: SNHL increased to 84% in patients who had received CRT, compared with 26% increasing in patients who had treated with RT. There was an increased risk of SNHL at all frequencies for ears received a cochlear mean dose >50 Gy in RT group, compared to those receiving cochlear mean dose >30 Gy in CRT group. SNHL was more severe at higher frequencies in both patient groups. Conclusion: Characteristic of radiation-induced SNHL is different from CRT-induced SNHL, especially in threshold radiation dose and PTA frequency. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.