Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression

Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression Publisher Pubmed

Li L ; Yao M ; Meng J ; Zhong Z ; Nan N ; Kazemi AH ; Guo J ; Liu C ; Jiang Y

Source: Annals of Medicine Published:2026

Abstract

Background: The increasing global burden of depression underscores the need for novel therapeutic strategies beyond conventional antidepressants such as selective serotonin reuptake inhibitors and serotonin–norepinephrine reuptake inhibitors. Given the substantial role of calcium signaling in the pathogenesis of psychiatric disorders, this review examines its critical involvement in depression to guide future research and clinical advancements. Results: We describe the activation mechanisms of key calcium pathways, including voltage-gated channels, N-methyl-D-aspartate receptor–gated channels, endoplasmic reticulum–mediated release, and store-operated calcium entry, and summarize evidence of their dysregulation in clinical depression and animal models.Furthermore, we discuss the potential of calcium signaling as a diagnostic and prognostic biomarker, highlighting how emerging insights in this field may support the development of targeted antidepressant therapies. Conclusions: This review indicates that calcium signaling demonstrates potential as a diagnostic biomarker and a basis for targeted antidepressant therapies. © 2026 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Style	Citing Format
MLA	Li L, et al.. "Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression." Annals of Medicine, vol. 58, no. 1, 2026, pp. -.
APA	Li L, Yao M, Meng J, Zhong Z, Nan N, Kazemi AH, Guo J, Liu C, Jiang Y (2026). Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression. Annals of Medicine, 58(1), -.
Chicago	Li L, Yao M, Meng J, Zhong Z, Nan N, Kazemi AH, Guo J, Liu C, Jiang Y. "Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression." Annals of Medicine 58, no. 1 (2026): -.
Harvard	Li L et al. (2026) 'Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression', Annals of Medicine, 58(1), pp. -.
Vancouver	Li L, Yao M, Meng J, Zhong Z, Nan N, Kazemi AH, et al.. Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression. Annals of Medicine. 2026;58(1):-.
BibTex	@article{ author = {Li L and Yao M and Meng J and Zhong Z and Nan N and Kazemi AH and Guo J and Liu C and Jiang Y}, title = {Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression}, journal = {Annals of Medicine}, volume = {58}, number = {1}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Li L AU - Yao M AU - Meng J AU - Zhong Z AU - Nan N AU - Kazemi AH AU - Guo J AU - Liu C AU - Jiang Y TI - Advances in Calcium Signalling Research for the Diagnosis and Treatment of Depression JO - Annals of Medicine VL - 58 IS - 1 SP - EP - PY - 2026 ER -

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