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Human Split-Thickness Skin Allograft From Brain-Dead Donors



Khodadadi A1 ; Olang O2 ; Makhllough A3 ; Nozary Heshmati B1 ; Azmoudeh Ardalan F1 ; Tavakoli SA1
Authors

Source: International Journal of Organ Transplantation Medicine Published:2016

Abstract

Background: Looking for an appropriate skin substitute for temporary and permanent coverage of wounds remains one of the main obstacles of medical researchers. Objective: To investigate the rate of inflammation, symbiosis, and survival of grafted allograft skin from brain-dead donors (BDDs) in rabbits. Methods: After receiving negative serologic tests of BDDs, we prepared partial thickness skin grafts. They were then used in treating wounds of 5 rabbits in comparison with split-thickness skins taken from cardiac dead donors. Results: On histopathological examinations, we found no difference between the skins. All samples were separated from the baseline in 15-20 days. Conclusion: Gamma-irradiated freeze-dried human split-thickness skin taken from BDDs is safe and can be used for the treatment of deep skin burns.
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