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Neuroscience-Informed Classification of Prevention Interventions in Substance Use Disorders: An Rdoc-Based Approach Publisher Pubmed



Rezapour T1 ; Rafei P3 ; Baldacchino A4 ; Conrod PJ5 ; Dom G6 ; Fishbein DH7, 8 ; Kazemi A1 ; Hendriks V9, 10 ; Newton N11 ; Riggs NR12 ; Squeglia LM13 ; Teesson M11 ; Vassileva J14 ; Verdejogarcia A15 Show All Authors
Authors
  1. Rezapour T1
  2. Rafei P3
  3. Baldacchino A4
  4. Conrod PJ5
  5. Dom G6
  6. Fishbein DH7, 8
  7. Kazemi A1
  8. Hendriks V9, 10
  9. Newton N11
  10. Riggs NR12
  11. Squeglia LM13
  12. Teesson M11
  13. Vassileva J14
  14. Verdejogarcia A15
  15. Ekhtiari H2

Source: Neuroscience and Biobehavioral Reviews Published:2024


Abstract

Neuroscience has contributed to uncover the mechanisms underpinning substance use disorders (SUD). The next frontier is to leverage these mechanisms as active targets to create more effective interventions for SUD treatment and prevention. Recent large-scale cohort studies from early childhood are generating multiple levels of neuroscience-based information with the potential to inform the development and refinement of future preventive strategies. However, there are still no available well-recognized frameworks to guide the integration of these multi-level datasets into prevention interventions. The Research Domain Criteria (RDoC) provides a neuroscience-based multi-system framework that is well suited to facilitate translation of neurobiological mechanisms into behavioral domains amenable to preventative interventions. We propose a novel RDoC-based framework for prevention science and adapted the framework for the existing preventive interventions. From a systematic review of randomized controlled trials using a person-centered drug/alcohol preventive approach for adolescents, we identified 22 unique preventive interventions. By teasing apart these 22 interventions into the RDoC domains, we proposed distinct neurocognitive trajectories which have been recognized as precursors or risk factors for SUDs, to be targeted, engaged and modified for effective addiction prevention. © 2024 Elsevier Ltd
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