Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection Publisher Pubmed

Venkatesan S¹ ; Myles PR¹ ; Bolton KJ² ; Muthuri SG³ ; Al Khuwaitir T⁴ ; Anovadiya AP⁵ ; Azzizbaumgartner E⁶ ; Bajjou T⁷ ; Bassetti M⁸ ; Beovic B⁹ ; Bertisch B¹⁰ ; Bonmarin I¹¹ ; Booy R¹² ; Borjaaburto VH¹³ Show All Authors

Venkatesan S¹
Myles PR¹
Bolton KJ²
Muthuri SG³
Al Khuwaitir T⁴
Anovadiya AP⁵
Azzizbaumgartner E⁶
Bajjou T⁷
Bassetti M⁸
Beovic B⁹
Bertisch B¹⁰
Bonmarin I¹¹
Booy R¹²
Borjaaburto VH¹³
Burgmann H¹⁴
Cao B¹⁵
Carratala J¹⁶
Chinbayar T¹⁷
Cilloniz C¹⁸
Denholm JT¹⁹
Dominguez SR²⁰
Duarte PAD²¹
Dubnovraz G²²
Fanella S²³
Gao Z²⁴
Gerardin P^{25, 26, 27}
Giannella M^{28, 29}
Gubbels S³⁰
Herberg J³¹
Higuera Iglesias AL³²
Hoeger PH³³
Hu XY³⁴
Islam QT³⁵
Jimenez MF³⁶
Keijzers G³⁷
Khalili H³⁸
Kusznierz G³⁹
Kuzman I⁴⁰
Langenegger E⁴¹
Lankarani KB⁴²
Leo YS⁴³
Libster RP^{44, 45, 46}
Linko R⁴⁷
Madanat F⁴⁸
Maltezos E⁴⁹
Mamun A⁵⁰
Manabe T⁵¹
Metan G⁵²
Mickiene A⁵³
Mikic D⁵⁴
Mohn KGI^{55, 56}
Oliva ME⁵⁷
Ozkan M⁵⁸
Parekh D⁵⁹
Paul M⁶⁰
Rath BA⁶¹
Refaey S⁶²
Rodriguez AH⁶³
Sertogullarindan B⁶⁴
Skretmagierlo J⁶⁵
Somer A⁶⁶
Talarek E⁶⁷
Tang JW^{68, 69, 70}
To K⁷¹
Tran D⁷²
Uyeki TM⁶
Vaudry W⁷³
Vidmar T⁷⁴
Zarogoulidis P⁷⁵
Nguyenvantam JS¹

Source: The Journal of infectious diseases Published:2020

Abstract

BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. RESULTS: We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI, .78-.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. CONCLUSIONS: When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Style	Citing Format
MLA	Venkatesan S, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases, vol. 221, no. 3, 2020, pp. 356-366.
APA	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borjaaburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, ... Nguyenvantam JS (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases, 221(3), 356-366.
Chicago	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases 221, no. 3 (2020): 356-366.
Harvard	Venkatesan S et al. (2020) 'Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection', The Journal of infectious diseases, 221(3), pp. 356-366.
Vancouver	Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, et al.. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases. 2020;221(3):356-366.
BibTex	@article{ author = {Venkatesan S and Myles PR and Bolton KJ and Muthuri SG and Al Khuwaitir T and Anovadiya AP and Azzizbaumgartner E and Bajjou T and Bassetti M and Beovic B and Bertisch B and Bonmarin I and Booy R and Borjaaburto VH and Burgmann H and Cao B and Carratala J and Chinbayar T and Cilloniz C and Denholm JT and Dominguez SR and Duarte PAD and Dubnovraz G and Fanella S and Gao Z and Gerardin P and Giannella M and Gubbels S and Herberg J and Higuera Iglesias AL and Hoeger PH and Hu XY and Islam QT and Jimenez MF and Keijzers G and Khalili H and Kusznierz G and Kuzman I and Langenegger E and Lankarani KB and Leo YS and Libster RP and Linko R and Madanat F and Maltezos E and Mamun A and Manabe T and Metan G and Mickiene A and Mikic D and Mohn KGI and Oliva ME and Ozkan M and Parekh D and Paul M and Rath BA and Refaey S and Rodriguez AH and Sertogullarindan B and Skretmagierlo J and Somer A and Talarek E and Tang JW and To K and Tran D and Uyeki TM and Vaudry W and Vidmar T and Zarogoulidis P and Nguyenvantam JS}, title = {Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection}, journal = {The Journal of infectious diseases}, volume = {221}, number = {3}, pages = {356-366}, year = {2020} }
RIS	TY - JOUR AU - Venkatesan S AU - Myles PR AU - Bolton KJ AU - Muthuri SG AU - Al Khuwaitir T AU - Anovadiya AP AU - Azzizbaumgartner E AU - Bajjou T AU - Bassetti M AU - Beovic B AU - Bertisch B AU - Bonmarin I AU - Booy R AU - Borjaaburto VH AU - Burgmann H AU - Cao B AU - Carratala J AU - Chinbayar T AU - Cilloniz C AU - Denholm JT AU - Dominguez SR AU - Duarte PAD AU - Dubnovraz G AU - Fanella S AU - Gao Z AU - Gerardin P AU - Giannella M AU - Gubbels S AU - Herberg J AU - Higuera Iglesias AL AU - Hoeger PH AU - Hu XY AU - Islam QT AU - Jimenez MF AU - Keijzers G AU - Khalili H AU - Kusznierz G AU - Kuzman I AU - Langenegger E AU - Lankarani KB AU - Leo YS AU - Libster RP AU - Linko R AU - Madanat F AU - Maltezos E AU - Mamun A AU - Manabe T AU - Metan G AU - Mickiene A AU - Mikic D AU - Mohn KGI AU - Oliva ME AU - Ozkan M AU - Parekh D AU - Paul M AU - Rath BA AU - Refaey S AU - Rodriguez AH AU - Sertogullarindan B AU - Skretmagierlo J AU - Somer A AU - Talarek E AU - Tang JW AU - To K AU - Tran D AU - Uyeki TM AU - Vaudry W AU - Vidmar T AU - Zarogoulidis P AU - Nguyenvantam JS TI - Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection JO - The Journal of infectious diseases VL - 221 IS - 3 SP - 356 EP - 366 PY - 2020 ER -

Style

Citing Format

MLA

Venkatesan S, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases, vol. 221, no. 3, 2020, pp. 356-366.

APA

Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, Bajjou T, Bassetti M, Beovic B, Bertisch B, Bonmarin I, Booy R, Borjaaburto VH, Burgmann H, Cao B, Carratala J, Chinbayar T, Cilloniz C, ... Nguyenvantam JS (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases, 221(3), 356-366.

Chicago

Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, Azzizbaumgartner E, et al.. "Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection." The Journal of infectious diseases 221, no. 3 (2020): 356-366.

Harvard

Venkatesan S et al. (2020) 'Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection', The Journal of infectious diseases, 221(3), pp. 356-366.

Vancouver

Venkatesan S, Myles PR, Bolton KJ, Muthuri SG, Al Khuwaitir T, Anovadiya AP, et al.. Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection. The Journal of infectious diseases. 2020;221(3):356-366.

BibTex

@article{ author = {Venkatesan S and Myles PR and Bolton KJ and Muthuri SG and Al Khuwaitir T and Anovadiya AP and Azzizbaumgartner E and Bajjou T and Bassetti M and Beovic B and Bertisch B and Bonmarin I and Booy R and Borjaaburto VH and Burgmann H and Cao B and Carratala J and Chinbayar T and Cilloniz C and Denholm JT and Dominguez SR and Duarte PAD and Dubnovraz G and Fanella S and Gao Z and Gerardin P and Giannella M and Gubbels S and Herberg J and Higuera Iglesias AL and Hoeger PH and Hu XY and Islam QT and Jimenez MF and Keijzers G and Khalili H and Kusznierz G and Kuzman I and Langenegger E and Lankarani KB and Leo YS and Libster RP and Linko R and Madanat F and Maltezos E and Mamun A and Manabe T and Metan G and Mickiene A and Mikic D and Mohn KGI and Oliva ME and Ozkan M and Parekh D and Paul M and Rath BA and Refaey S and Rodriguez AH and Sertogullarindan B and Skretmagierlo J and Somer A and Talarek E and Tang JW and To K and Tran D and Uyeki TM and Vaudry W and Vidmar T and Zarogoulidis P and Nguyenvantam JS}, title = {Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection}, journal = {The Journal of infectious diseases}, volume = {221}, number = {3}, pages = {356-366}, year = {2020} }

RIS

TY - JOUR
AU - Venkatesan S
AU - Myles PR
AU - Bolton KJ
AU - Muthuri SG
AU - Al Khuwaitir T
AU - Anovadiya AP
AU - Azzizbaumgartner E
AU - Bajjou T
AU - Bassetti M
AU - Beovic B
AU - Bertisch B
AU - Bonmarin I
AU - Booy R
AU - Borjaaburto VH
AU - Burgmann H
AU - Cao B
AU - Carratala J
AU - Chinbayar T
AU - Cilloniz C
AU - Denholm JT
AU - Dominguez SR
AU - Duarte PAD
AU - Dubnovraz G
AU - Fanella S
AU - Gao Z
AU - Gerardin P
AU - Giannella M
AU - Gubbels S
AU - Herberg J
AU - Higuera Iglesias AL
AU - Hoeger PH
AU - Hu XY
AU - Islam QT
AU - Jimenez MF
AU - Keijzers G
AU - Khalili H
AU - Kusznierz G
AU - Kuzman I
AU - Langenegger E
AU - Lankarani KB
AU - Leo YS
AU - Libster RP
AU - Linko R
AU - Madanat F
AU - Maltezos E
AU - Mamun A
AU - Manabe T
AU - Metan G
AU - Mickiene A
AU - Mikic D
AU - Mohn KGI
AU - Oliva ME
AU - Ozkan M
AU - Parekh D
AU - Paul M
AU - Rath BA
AU - Refaey S
AU - Rodriguez AH
AU - Sertogullarindan B
AU - Skretmagierlo J
AU - Somer A
AU - Talarek E
AU - Tang JW
AU - To K
AU - Tran D
AU - Uyeki TM
AU - Vaudry W
AU - Vidmar T
AU - Zarogoulidis P
AU - Nguyenvantam JS
TI - Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-Analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1n1) Virus Infection
JO - The Journal of infectious diseases
VL - 221
IS - 3
SP - 356
EP - 366
PY - 2020
ER -

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