Effects of High-Flux Hemodialysis on Hemoglobin and Phosphorus Levels: A Retrospective Cohort Study Publisher



Jalalabadi NZ ; Faraji N ; Khazaei MR ; Taghizadeh F ; Movahed SMM ; Farid AS ; Razavi E ; Oskouie IM ; Najafi M
Source: Translational Research in Urology Published:2025

Abstract

Introduction The purpose of this retrospective cohort study was to clarify the effect of high-flux hemodialysis on hemoglobin and phosphorus level in hemodialysis patients. Methods A retrospective cohort study was performed at the hemodialysis center of 22 Bahman Hospital of Mashhad, in which 30 end-stage renal disease (ESRD) participants were allocated randomly to receive high-flux or low-flux hemodialysis. Hemodialysis was applied three times a week for four hours each session. Biochemical parameters such as hemoglobin and phosphorus serum levels were assessed before and after three months of hemodialysis. Results The average age of 30 ESRD patients who met the inclusion criteria was 56.7 years. After three-month hemodialysis course, serum phosphorus level showed significant reduction in high-flux group (P-value=0.0001), while there was no significant difference for low-flux group (P-value=0.740). Hemoglobin levels in the pre-and post-dialysis stage did not differ significantly in the high-flux or low-flux group (P-value>0.05). High-flux dialysis resulted in significantly more reduction in phosphorus level than low-flux dialysis (P-value=0.003); however, regarding changes in hemoglobin levels, no considerable difference was reported among both groups (P-value=0.834). Conclusions We found that the use of high-flux hemodialysis has a positive effect on reducing the level of phosphorus, but it may require a longer duration of treatment to be effective on the other parameters such as hemoglobin, hematocrit, PTH and ferritin. Copyright © 2025 Urology Research Center (URC), Tehran University of Medical Sciences.