Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders

Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders Publisher

Shams Nosrati M S ; Doustmohammadi M ; Dostmohammadi A ; Kakavand Hamidi A ; Boogari M ; Hoseini Tavassol Z ; Khosravinejat S ; Asgari M ; Shafiei M ; Nemati A H ; Romano F ; Capra V ; Sterlini B ; Darbalaei M Show All Authors

Shams Nosrati M S
Doustmohammadi M
Dostmohammadi A
Kakavand Hamidi A
Boogari M
Hoseini Tavassol Z
Khosravinejat S
Asgari M
Shafiei M
Nemati A H
Romano F
Capra V
Sterlini B
Darbalaei M
Salehi M
Omrani M D
Zara F
Kibar Z
Miyamoto T
Scala M

Source: Current Issues in Molecular Biology Published:2026

Abstract

The development and maintenance of the nervous system depend on a tightly regulated intracellular transport network in which kinesin superfamily (KIF) motor proteins drive microtubule-based delivery of synaptic vesicle precursors, organelles, mRNAs, and signaling components along axons and dendrites. Disruption of this machinery underlies a clinically heterogeneous spectrum of neurodevelopmental disorders (NDDs), including intellectual disability, epilepsy, autism spectrum disorder, microcephaly, malformations of cortical development, spasticity, and axonal neuropathy. Here, we synthesize current knowledge on how kinesin dysfunction shapes neurodevelopment. We outline the physiological roles of kinesins in neuronal polarity, organelle and mitochondrial positioning, synaptogenesis, and progenitor division, and survey principal disease-associated genes, including KIF1A, KIF5A, KIF7, KIF11, KIF2A, KIF5C, and emerging members such as KIF14, KIF15, and KIF16B. We detail how distinct pathogenic mechanisms, such as loss of motility, impaired cargo coupling, motor hyperactivity, mitotic spindle defects, and disrupted ciliary signaling, converge on shared cellular endpoints, and how tubulin isotypes and posttranslational modifications further modulate motor output. In this review, we discuss translational implications, including variant-resolved diagnosis and precision strategies to restore transport, dampen pathological hyperactivity, or stabilize the microtubule track. Collectively, these advances reframe kinesinopathies as mechanistically stratified disorders of neuronal transport. © 2026 by the authors.

Style	Citing Format
MLA	Shams Nosrati M S, et al.. "Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders." Current Issues in Molecular Biology, vol. 48, no. 8, 2026, pp. -.
APA	Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, Khosravinejat S, Asgari M, Shafiei M, Nemati A H, Romano F, Capra V, Sterlini B, Darbalaei M, Salehi M, Omrani M D, Zara F, Kibar Z, Miyamoto T, Scala M (2026). Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders. Current Issues in Molecular Biology, 48(8), -.
Chicago	Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, Khosravinejat S, et al.. "Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders." Current Issues in Molecular Biology 48, no. 8 (2026): -.
Harvard	Shams Nosrati M S et al. (2026) 'Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders', Current Issues in Molecular Biology, 48(8), pp. -.
Vancouver	Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, et al.. Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders. Current Issues in Molecular Biology. 2026;48(8):-.
BibTex	@article{ author = {Shams Nosrati M S and Doustmohammadi M and Dostmohammadi A and Kakavand Hamidi A and Boogari M and Hoseini Tavassol Z and Khosravinejat S and Asgari M and Shafiei M and Nemati A H and Romano F and Capra V and Sterlini B and Darbalaei M and Salehi M and Omrani M D and Zara F and Kibar Z and Miyamoto T and Scala M}, title = {Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders}, journal = {Current Issues in Molecular Biology}, volume = {48}, number = {8}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Shams Nosrati M S AU - Doustmohammadi M AU - Dostmohammadi A AU - Kakavand Hamidi A AU - Boogari M AU - Hoseini Tavassol Z AU - Khosravinejat S AU - Asgari M AU - Shafiei M AU - Nemati A H AU - Romano F AU - Capra V AU - Sterlini B AU - Darbalaei M AU - Salehi M AU - Omrani M D AU - Zara F AU - Kibar Z AU - Miyamoto T AU - Scala M TI - Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders JO - Current Issues in Molecular Biology VL - 48 IS - 8 SP - EP - PY - 2026 ER -

Style

Citing Format

MLA

Shams Nosrati M S, et al.. "Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders." Current Issues in Molecular Biology, vol. 48, no. 8, 2026, pp. -.

APA

Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, Khosravinejat S, Asgari M, Shafiei M, Nemati A H, Romano F, Capra V, Sterlini B, Darbalaei M, Salehi M, Omrani M D, Zara F, Kibar Z, Miyamoto T, Scala M (2026). Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders. Current Issues in Molecular Biology, 48(8), -.

Chicago

Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, Khosravinejat S, et al.. "Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders." Current Issues in Molecular Biology 48, no. 8 (2026): -.

Harvard

Shams Nosrati M S et al. (2026) 'Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders', Current Issues in Molecular Biology, 48(8), pp. -.

Vancouver

Shams Nosrati M S, Doustmohammadi M, Dostmohammadi A, Kakavand Hamidi A, Boogari M, Hoseini Tavassol Z, et al.. Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders. Current Issues in Molecular Biology. 2026;48(8):-.

BibTex

@article{ author = {Shams Nosrati M S and Doustmohammadi M and Dostmohammadi A and Kakavand Hamidi A and Boogari M and Hoseini Tavassol Z and Khosravinejat S and Asgari M and Shafiei M and Nemati A H and Romano F and Capra V and Sterlini B and Darbalaei M and Salehi M and Omrani M D and Zara F and Kibar Z and Miyamoto T and Scala M}, title = {Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders}, journal = {Current Issues in Molecular Biology}, volume = {48}, number = {8}, pages = {-}, year = {2026} }

RIS

TY - JOUR
AU - Shams Nosrati M S
AU - Doustmohammadi M
AU - Dostmohammadi A
AU - Kakavand Hamidi A
AU - Boogari M
AU - Hoseini Tavassol Z
AU - Khosravinejat S
AU - Asgari M
AU - Shafiei M
AU - Nemati A H
AU - Romano F
AU - Capra V
AU - Sterlini B
AU - Darbalaei M
AU - Salehi M
AU - Omrani M D
AU - Zara F
AU - Kibar Z
AU - Miyamoto T
AU - Scala M
TI - Traffic Jams in the Brain: How Kinesin Dysfunction Shapes Neurodevelopmental Disorders
JO - Current Issues in Molecular Biology
VL - 48
IS - 8
SP -
EP -
PY - 2026
ER -

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