Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Microbial Natural Compounds and Secondary Metabolites As Immunomodulators: A Review Publisher Pubmed



Mahmoudi F1 ; Jalayeri MHT2 ; Montaseri A3 ; Mohamedkhosroshahi L4 ; Baradaran B1
Authors

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties. The discovery of many natural compounds derived from bacterial sources, such as secondary metabolites with promising immunomodulating activities, represents the importance of this topic in drug discovery and emphasizes the necessity for a coherent source of study in this area. Considering this need, in this review, we aim to focus on the current information about the immunomodulatory effects of bacterial secondary metabolites and natural immunomodulators derived from microorganisms. © 2024 Elsevier B.V.
Related Docs
View other Related Docs
1. Introduction on Treatment for Infectious Diseases and Immunological Disorders, Encyclopedia of Infection and Immunity (2022)
2. Antimicrobial Peptides (Amps): Roles, Functions and Mechanism of Action, International Journal of Peptide Research and Therapeutics (2020)
3. Intestinal Microbiota: Novel Personalized Cancer Immunotherapy in Colorectal Cancer, International Archives of Allergy and Immunology (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Bagher Larijani (2)
Other Related Docs
4. An Update on the Effects of Probiotics on Gastrointestinal Cancers, Frontiers in Pharmacology (2021)
5. Synthesis of New 2-(5-(5-Nitrofuran-2-Yl)-1,3,4-Thiadiazol-2-Ylimino)Thiazolidin-4-One Derivatives As Anti-Mrsa and Anti-H. Pylori Agents, BMC Chemistry (2022)
6. A Single Key for Many Doors? Unlocking the Bio-Chemical Potential of Lactobacillus Bulgaricus Metabolic Postbiotic, Probiotics and Antimicrobial Proteins (2025)
7. Dual Role of Microbiota-Derived Short-Chain Fatty Acids on Host and Pathogen, Biomedicine and Pharmacotherapy (2022)
8. Bacteria-Derived Chimeric Toxins As Potential Anticancer Agents, Frontiers in Oncology (2022)
9. Fighting Parasites During the Post-Antibiotic Era, Advances in Antiparasitic Therapies and Drug Delivery (2023)
10. The Effects of Probiotics, Prebiotics and Synbiotics on the Reduction of Ibd Complications, a Periodic Review During 2009–2020, Journal of Applied Microbiology (2021)
11. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)
12. Ginger Extract Improves Cognitive Dysfunction Via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease, Molecular Neurobiology (2025)
13. New 7-Piperazinylquinolones Containing (Benzo[D]Imidazol-2-Yl)Methyl Moiety As Potent Antibacterial Agents, Molecular Diversity (2018)
14. Postbiotic As Novel Alternative Agent or Adjuvant for the Common Antibiotic Utilized in the Food Industry, Current Pharmaceutical Biotechnology (2024)
15. The Potential Use of Bacteria and Bacterial Derivatives As Drug Delivery Systems for Viral Infection, Virology Journal (2023)
16. Effect of Ethanolic Extract of Zataria Multiflora Boiss (Shiraz Thyme Extract) on the Kidney and Spleen Tissues of Mice Infected With Visceral Candidiasis and the Stimulation of Th1, Th17, and Treg Immune Cells, Reviews and Research in Medical Microbiology (2020)
17. The Strategic Role of Biotics in Dental Caries Prevention: A Scoping Review, Food Science and Nutrition (2024)
18. Clinical Application of Gut Microbiota Metabolites: A Novel Opportunity in Personalized Medicine, Koomesh (2022)
19. Characterization of Gut Microbiota Profile in Iranian Patients With Bipolar Disorder Compared to Healthy Controls, Frontiers in Cellular and Infection Microbiology (2023)
20. Poxviruses and the Immune System: Implications for Monkeypox Virus, International Immunopharmacology (2022)