Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran

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Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran

Noori B ; Shahnavaz V ; Bahavar A ; Sharifi Z ; Kafialqora P ; Navi Z ; Foroushani AR ; Shafiei M ; Jazayeri SM ; Mozhgani SH ; Norouzi M

Source: Iranian Journal of Public Health Published:2025

Abstract

Background: Human T-lymphotropic virus type 1 (HTLV-1) is considered a health issue in Iran. However, its genetic diversity and molecular epidemiologic phylogeny remain poorly characterized. Methods: The Tax gene of 9 asymptomatic individuals across Alborz, Gilan, and Ardabil provinces of Iran was sequenced and analyzed phylogenetically using MEGA-X. Results: All strains clustered within the Cosmopolitan subtype a, showing high genetic similarity to Japanese and Chinese references. Positive selection (dN/dS > 1) was observed in all samples. Strikingly, the Alborz ISO32 strain exhibited 10 unique nonsynonymous mutations, suggesting regional evolutionary divergence. Conclusion: This study, as the first multi-provincial study in Iran, reveals the essential requirement for systematic tracking of HTLV-1 genetic diversity and designing prevention programs tailored to each region. Copyright © 2025 Noori et al.

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Style	Citing Format
MLA	Noori B, et al.. "Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran." Iranian Journal of Public Health, vol. 54, no. 12, 2025, pp. 2764-2772.
APA	Noori B, Shahnavaz V, Bahavar A, Sharifi Z, Kafialqora P, Navi Z, Foroushani AR, Shafiei M, Jazayeri SM, Mozhgani SH, Norouzi M (2025). Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran. Iranian Journal of Public Health, 54(12), 2764-2772.
Chicago	Noori B, Shahnavaz V, Bahavar A, Sharifi Z, Kafialqora P, Navi Z, Foroushani AR, et al.. "Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran." Iranian Journal of Public Health 54, no. 12 (2025): 2764-2772.
Harvard	Noori B et al. (2025) 'Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran', Iranian Journal of Public Health, 54(12), pp. 2764-2772.
Vancouver	Noori B, Shahnavaz V, Bahavar A, Sharifi Z, Kafialqora P, Navi Z, et al.. Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran. Iranian Journal of Public Health. 2025;54(12):2764-2772.
BibTex	@article{ author = {Noori B and Shahnavaz V and Bahavar A and Sharifi Z and Kafialqora P and Navi Z and Foroushani AR and Shafiei M and Jazayeri SM and Mozhgani SH and Norouzi M}, title = {Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran}, journal = {Iranian Journal of Public Health}, volume = {54}, number = {12}, pages = {2764-2772}, year = {2025} }
RIS	TY - JOUR AU - Noori B AU - Shahnavaz V AU - Bahavar A AU - Sharifi Z AU - Kafialqora P AU - Navi Z AU - Foroushani AR AU - Shafiei M AU - Jazayeri SM AU - Mozhgani SH AU - Norouzi M TI - Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1 (Htlv-1) in Three Provinces of Iran JO - Iranian Journal of Public Health VL - 54 IS - 12 SP - 2764 EP - 2772 PY - 2025 ER -

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