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Ultrasensitive Electrochemical Detection of Cancer Cell Using Modified Graphene Nanostructures Publisher



Mirhosseini M1, 2 ; Omrani MD3, 4 ; Shayeh JS5 ; Rahimpour A6 ; Haghiralsadat F2 ; Mansouri V3, 4 ; Omidi M5
Authors

Source: Oriental Journal of Chemistry Published:2017


Abstract

In this paper the ultra sensitive electrochemical cytosensor was introduced for prostate cancer cells (Du-145) detection. In this cytosensor Du-145 cells were captured on modified gold electrode by using CD-166 antibody. Also reduced graphene oxide/ gold nanoparticle/ CD-166- horseradish peroxidase (rGO/ AuNP/Ab-HRP) nanoprobes as efficient signal amplifiers was designed for the cancer cells recognition.The presented cytosensor exhibited a good cell-capture ability, wide detection range and low detection limit of 50 cells.This cytosensor has great potential for cancer cell detection in clinical and pathological application. © 2017, Oriental Scientific Publishing Company. All rights reserved.
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