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Pegylated Superparamagnetic Iron Oxide Nanoparticles Labeled With 68Ga As a Pet/Mri Contrast Agent: A Biodistribution Study Publisher



Lahooti A1 ; Sarkar S1, 2 ; Saligheh Rad H1, 3 ; Gholami A4 ; Nosrati S5 ; Muller RN6, 7 ; Laurent S6, 7 ; Gruttner C8 ; Geramifar P9 ; Yousefnia H10 ; Mazidi M10 ; Shanehsazzadeh S6
Authors

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2017


Abstract

The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies. © 2016, Akademiai Kiado, Budapest, Hungary.
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