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Eco-Friendly, Green and New Metal-Free Intramolecular Friedel–Crafts Reaction to Synthesis of Acridones Derivatives Using Phenylboronic Acid Derivatives Publisher



Askarzadeh M1 ; Moazzam A2 ; Sayahi MH3 ; Fouladvand A2 ; Adib M1 ; Mahdavi M2
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Source: Tetrahedron Letters Published:2023


Abstract

Herein, we report a new, facile, versatile metal-free method for preparation of the various Acridones through an intramolecular carbonylation of 2-(phenylamino)benzoic acid derivatives and phenylboronic acid derivatives as activating agent for activation of carboxylic acid group in intramolecular C[sbnd]C bond formation through Friedel–Crafts reaction. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of the Acridones in good to excellent yields. © 2023 Elsevier Ltd
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