Correlation Between Component-Resolved Diagnostics (Crd) and Clinical Symptoms in Allergic Children: A One-Year Study at the Children's Medical Center (April 2023–March 2024) Publisher Pubmed



Khoshkam M ; Movahedi M ; Gharagozlou M ; Soltani MF ; Movahedi M
Source: Iranian Journal of Allergy, Asthma and Immunology Published:2026

Abstract

Component- Resolved Diagnosis (CRD) is an effective tool in allergy diagnosis, that detects specific IgE to allergenic molecules. The ALEX (Allergy Explorer) test, commercially available since 2019, measures specific IgE to allergenic extracts and components associated with inhalant, food, animal, latex, and insect allergens. CRD results should be interpreted based on the patient's clinical history. Since Children's Medical Center Hospital is one of the largest referral centers for allergic patients, we evaluated the results of the ALEX2 test in patients referred to this center and compared them with the patients’ clinical symptoms. Clinical symptoms were concordant with positive CRD (ALEX2) test in 76.7% of cases. The overall agreement between positive allergen components and clinical symptoms was 58%. These findings indicate that the ALEX2 test can improve diagnostic accuracy in allergic patients; however, positive test results should be interpreted in the context of the patient’s clinical history. Copyright © 2026 Khoshkam et al.