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Evaluation of Conventional Treatment Planning Techniques for Radiotherapy of Gastroesophageal Junction Cancer: A Dosimetric Comparison Between Male and Female Patients Publisher



M Pursamimi MOHAMAD ; M Ghorbani MAHDI ; M Khosravi MEHDI ; G Mehrikakavand GHAZAL ; W Parwaie WRYA ; Sm Hosseini Seyyed MOHAMMAD ; Am Sharifi Ali MOHAMMAD ; M Tavakoli MEYSAM
Authors

Source: Frontiers in Biomedical Technologies Published:2025


Abstract

Purpose: Gastro-Esophageal (GE) junction cancer has been increasingly prevalent worldwide. This study aims to compare dosimetric and radiobiological parameters for target areas and Organs At Risk (OARs) in men and women patients diagnosed with GE junction cancer. Materials and Methods: Here, thirty patients who underwent radiotherapy using a 6-MV photon beam from a linear accelerator (Shinva Medical, Shandong, China) were selected. Dosimetric and radiobiological parameters within the Planning Target Volume (PTV) and OARs were compared among all patients using a paired-sample t-test. Additionally, a comparative analysis of Field-In-Field (FIF), three-Field (3F), and four-Field Box (4FB) planning techniques was conducted for both men and women patients. Results: In terms of dose distribution in the PTV, a significant difference exists between male and female patients regarding TCP and Monitor Unit (MU). Furthermore, in terms of dose distribution in OARs, there is also a significant difference between males and females in terms of NTCP for the right lung and V20 Gy for the right lung. Conclusion: In general, most dosimetric parameters exhibited similarities between male and female patients. However, notable differences surfaced in TCP, MU, and specific parameters, including NTCP and V20Gy for the right lung. Hence, it is prudent to emphasize meticulous attention in treatment planning for GE junction cancer, considering the anatomical variations between males and females. © 2025 Elsevier B.V., All rights reserved.
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