Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Inhibitory Effect of a Lactobacillus Acidophilus Derived Biosurfactant on Serratia Marcescens Biofilm Formation



Shokouhfard M1 ; Kasra Kermanshahi R1 ; Vahedi Shahandashti R1 ; Feizabadi MM2 ; Teimourian S3
Authors

Source: Iranian Journal of Basic Medical Sciences Published:2015

Abstract

Objective(s): Serratia marcescens is one of the nosocomial pathogen. The ability to form biofilm is an important feature in the pathogenesis of S. marcescens. The aim of this study was to determine the anti‐adhesive properties of a biosurfactant isolated from Lactobacillus acidophilus ATCC 4356, on S. marcescens strains. Materials and Methods: Lactobacillus acidophilus ATCC 4356, was selected as a probiotic strain to produce biosurfactant. Anti‐adhesive activities was determined by pre‐coating and co‐ incubating methods in 96‐well culture plates. Results: The FTIR analysis of derived biosurfactant revealed the composition as protein component. Because of the release of such biosurfactants, L. acidophilus was able to interfere with the adhesion and biofilm formation of the S. marcescens strains. In co‐ incubation method this biosurfactant in 2.5 mg/ml concentration showed anti‐adhesive activity against all tested strains of S. marcescens (P<0.05). Conclusion: Our results show anti‐adhesive properties of L. acidophilus biosurfactant will be useful against microorganisms responsible for infections in the urinary, vaginal and gastrointestinal tracts, as well as skin, making it a suitable alternative to conventional antibiotics. © 2015, Mashhad University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Lactobacillus Spp. Derived Biosurfactants Effect on Expression of Genes Involved in Proteus Mirabilis Biofilm Formation, Infection# Genetics and Evolution (2022)
2. In Vitro Anti-Biofilm and Anti-Adhesion Effects of Lactic Acid Bacteria-Derived Biosurfactants Against Streptococcus Mutans, Infectious Disorders - Drug Targets (2025)
3. The Potential Effectiveness of Probiotic-Based Sanitation Procedures in Nosocomial Infection Control: A Review Article, Avicenna Journal of Environmental Health Engineering (2019)
Experts (# of related papers)
View all Related Experts
Abbas Bahador (3)
Nasrin Samadi (3)
Other Related Docs
4. Advanced Strategies for Combating Bacterial Biofilms, Journal of Cellular Physiology (2019)
5. Effect of Bacteriocin Produced by Lactobacillus Casei With Probiotic Potential Isolated From Milk on the Ability of Biofilm Production by Streptococcus Salivarius Obtained From Dental Plaque, Journal of Mazandaran University of Medical Sciences (2021)
6. Evaluation of Anti-Oxidant and Anti-Biofilm Activities of Biogenic Surfactants Derived From Bacillus Amyloliquefaciens and Pseudomonas Aeruginosa, Iranian Journal of Pharmaceutical Research (2020)
7. Antagonistic Activities of Some Probiotic Lactobacilli Culture Supernatant on Serratia Marcescens Swarming Motility and Antibiotic Resistance, Iranian Journal of Microbiology (2017)
8. Development of an Enzyme-Enhancer System to Improve Laccase Biological Activities, International Journal of Biological Macromolecules (2021)
9. Improved Infectious Burn Wound Healing by Applying Lyophilized Particles Containing Probiotics and Prebiotics, International Journal of Pharmaceutics (2023)
10. Lactobacillus Crispatus and Human Herpes Simplex Virus-2, an in Vitro Study, Molecular Genetics# Microbiology and Virology (2023)
11. Ex Vivo Comparison of Antibacterial Efficacy of Conventional Chemomechanical Debridement Alone and in Combination With Light-Activated Disinfection and Laser Irradiation Against Enterococcus Faecalis Biofilm, Photodiagnosis and Photodynamic Therapy (2020)
12. Antibacterial, Antifungal and Antioxidant Activities of Bee Glue Ethanol and Aqueous Extracts, Journal of Biological Research (Italy) (2017)
13. Comparison of Biofilm-Producing Ability of Clinical Isolates of Candida Parapsilosis Species Complex, Journal de Mycologie Medicale (2019)
14. Evaluation of the Antibacterial Activity of a Conventional Orthodontic Composite Containing Silver/Hydroxyapatite Nanoparticles, Progress in Orthodontics (2016)
15. Novel Silicon Dioxide -Based Nanocomposites As an Antimicrobial in Poly (Lactic Acid) Nanocomposites Films, Nanomedicine Research Journal (2018)
16. Antibacterial Efficacy of Antibiotic Pastes Versus Calcium Hydroxide Intracanal Dressing: A Systematic Review and Meta-Analysis of Ex Vivo Studies, Journal of Conservative Dentistry (2022)
17. Biofilm Formation in Staphylococcus Epidermidis Isolated From Hospitalized Patients, Archives of Clinical Infectious Diseases (2019)
18. Investigation of the Effect of Probiotics and Specific Bacteriophages on the Biofilm Formed by Streptococcus Mutans, Microbe (Netherlands) (2025)
19. Antifungal Efficacy of a Permanent Silicon Soft Liner Containing Silver Nanoparticles, Frontiers in Dentistry (2021)
20. Evaluation of Anti-Biofilm Potential of Biosurfactant Extracted From Nocardia Species; [Оценка Антибиоплёночного Потенциала Биосурфактанта, Выделенного Из Видов Nocardia], Folia Medica (2021)