Low Expression of Long Noncoding Rna Irain Is Associated With Poor Prognosis in Non-M3 Acute Myeloid Leukemia Patients Publisher Pubmed



Pashaiefar H¹ ; Izadifard M² ; Yaghmaie M¹ ; Montazeri M¹ ; Gheisari E¹ ; Ahmadvand M¹ ; Momeny M¹ ; Ghaffari SH¹ ; Kasaeian A¹ ; Alimoghaddam K¹ ; Ghavamzadeh A¹
Source: Genetic Testing and Molecular Biomarkers Published:2018

Abstract

Aims: Deregulation of the long noncoding RNA IRAIN has been identified in several cancers. However, the expression pattern of IRAIN and its clinical implication in acute myeloid leukemia (AML) are unknown. The purpose of this study was to investigate the expression status of IRAIN and its clinical significance in non-M3 AML patients. Methods: Quantitative reverse transcription-polymerase chain reaction was performed to examine IRAIN transcript levels in 64 de novo non-M3 AML patients and 51 healthy controls. The association of IRAIN expression with clinicopathological factors was statistically analyzed. Results: Compared with the controls, IRAIN was significantly downregulated in non-M3 AML patients (p < 0.001). The median of IRAIN expression divided the non-M3 AML patients into IRAIN low-expressing (IRAINlow) and IRAIN high-expressing (IRAINhigh) groups. The IRAINlow group tended to have higher white blood cell count and blast counts and had markedly shorter overall survival (OS) and relapse-free survival (RFS) (p = 0.044 and 0.009, respectively). In addition, patients with refractory response to chemotherapies and those with subsequent relapse had lower initial IRAIN expression. Multivariate analysis further identified IRAIN transcript levels as an independent prognostic factor for both RFS and OS. Conclusions: Our finding suggests that IRAIN transcript levels may be a useful biomarker for the prognosis of non-M3 AML patients. © 2018 Mary Ann Liebert, Inc.