Microfluidic-Assisted Synthesis and Modelling of Monodispersed Magnetic Nanocomposites for Biomedical Applications Publisher



Sartipzadeh O¹ ; Naghib SM¹ ; Shokati F² ; Rahmanian M² ; Majidzadeha K² ; Zare Y² ; Rhee KY³
Source: Nanotechnology Reviews Published:2020

Abstract

Droplet microfluidic was devoted to design and fabricate robust devices in the field of biosensing, tissue engineering, drug delivery, cell encapsulation, cell isolation, and lab-on-a-chip. Chitosan was widely used for different biomedical applications because of its unique characteristics such as antibacterial bioactivities, immune-enhancing influences, and anticancer bioactivities. In this research, a model is used for investigating the formation and size of composite droplets in a microfluidic device. The role of the velocity flow ratio in the composite droplet characteristics such as the generation rate and composite droplet size is described. According to the results, a desirable protocol is developed to control the properties of the composite droplets and to compare the size and rate of the composite droplets in a micro device. Furthermore, the level set laminar two-phase flow approach is exploited for studying the composite droplet-breaking procedure. An experimental procedure is used for validation of the simulation process. Various sizes and geometries of the composite droplets are fabricated to depict a potential in biomedical applications such as bioimaging, biosensing, tissue engineering, drug delivery, cell encapsulation, cancer cell isolation, and lab-on-a-chip. © 2020 Omid Sartipzadeh et al., published by De Gruyter 2020.