Synthesis and Evaluation of Ethyl 2,4-Dioxo-4-Arylbutanoate Derivatives As Src Kinase Inhibitors



Rafinejad A¹ ; Fallahtafti A¹ ; Tiwari R² ; Shirazi AN² ; Mandal D² ; Parang K² ; Foroumadi A³ ; Akbarzadeh T^{1, 4}
Source: Journal of Sciences# Islamic Republic of Iran Published:2015

Abstract

In this work, different ethyl 2,4-dioxo-4-arylbutanoate derivatives were prepared and evaluated for their Src Kinase inhibitory activity. For this purpose, the appropriate substituted acetophenone derivatives reacted with diethyl oxalate in the presence of sodium ethoxide in dried ethanol to give the corresponding products. All compounds showed moderate activities comparing with staurosporine as the reference drug.