The Influence of Dopaminergic System in Medial Prefrontal Cortex on Ketamine-Induced Amnesia in Passive Avoidance Task in Mice Publisher Pubmed



Farahmandfar M^{1, 2} ; Bakhtazad A^{1, 2} ; Akbarabadi A^{2, 3} ; Zarrindast MR^{1, 2, 4, 5, 6}
Source: European Journal of Pharmacology Published:2016

Abstract

Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice. Pre-training administration of ketamine (5, 10 and 15 mg/kg, i.p.) dose-dependently decreased the memory acquisition of a one-trial passive avoidance task. Pre-training intra-mPFC administration of SKF 38393, D1 receptor agonist and quinpirol D2 receptor agonist, alone did not affect memory acquisition. However, amnesia induced by pre-training ketamine (15 mg/kg) significantly decreased by pretreatment of SKF 38393 (2 and 4 μg/mouse) and quinpirol (0.3, 1 and 3 μg/mouse). Pre-training administration of SCH 23390, D1 receptor antagonist (0.75 and 1 μg/mouse, intra-mPFC), and sulpiride D2 receptor antagonist (3 μg/mouse, intra-mPFC) impaired memory acquisition. In addition, co-pretreatment of different doses of SCH 23390 and sulpiride with lower dose of ketamine (5 mg/kg), which did not induce amnesia by itself, caused inhibition of memory formation. It may be concluded that dopaminergic system of medial prefrontal cortex is involved in the ketamine-induced impairment of memory acquisition. © 2016 Elsevier B.V.