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Healthy Male Individuals Possess Higher Plasma Her-2 Level Than Females Publisher



Fateh ST1 ; Behgozin A2 ; Yekani F2 ; Geranpayeh L3 ; Olfatbakhsh A4 ; Moghadam S4 ; Sarramiforooshani R5 ; Salehinajafabadi A2, 6 ; Shekari F2, 7
Authors

Source: Cell Journal Published:2023


Abstract

Considering HER2 as one of the well-known biomarkers in the cancer field, and published articles regarding serum levels of HER2, in this paper we tried to highlight the issue that most studies don’t stratify the HER-2 concentration of individuals in terms of gender. In this brief survey, healthy individuals with no prior non-communicable diseases were categorized as males (n=34) and females (n=43), and all samples were evaluated for plasma HER-2 levels at once. Surprisingly, the plasma level of HER-2 of healthy male individuals (mean= 2.28 ± 0.21 ng/mL) was significantly (P<0.0001) higher than the plasma level of HER-2 of healthy females (mean: 0.06 ± 0.09 ng/mL), with no overlap. Therefore, we suggest that more studies are required to re-check the cutoff values for HER-2 plasma levels based on gender since the clinical implications of a unique HER-2 cutoff for both genders may be seriously concerning. © 2023 Royan Institute (ACECR). All rights reserved.
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