Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1

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Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1 Publisher Pubmed

Tavakoli A¹ ; Ataeipirkooh A¹ ; Mm Sadeghi G² ; Bokharaeisalim F¹ ; Sahrapour P³ ; Kiani SJ¹ ; Moghoofei M⁴ ; Farahmand M⁵ ; Javanmard D¹ ; Monavari SH¹

Source: Nanomedicine Published:2018

Abstract

Aim: We aimed to determine the possible inhibitory effects of zinc oxide nanoparticles (ZnO-NPs) and polyethylene glycol (PEG)-coated ZnO-NPs (ZnO-PEG-NPs) on herpes simplex virus type 1 (HSV-1). Materials & methods: PEGylated ZnO-NPs were synthesized by the mechanical method. Antiviral activity was assessed by 50% tissue culture infectious dose (TCID50) and real-time PCR assays. To confirm the antiviral activity of ZnO-NPs on expression of HSV-1 antigens, indirect immunofluorescence assay was also conducted. Results: 200 μg/ml ZnO-PEG-NPs could result in 2.5 log10 TCID50 reduction in virus titer, with inhibition rate of approximately 92% in copy number of HSV-1 genomic DNA. Conclusion: ZnO-PEG-NPs could be proposed as a new agent for efficient HSV-1 inhibition. Our results indicated that PEGylation is effective in reducing cytotoxicity and increasing antiviral activity of nanoparticles. © 2018 Future Medicine Ltd.

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Style	Citing Format
MLA	Tavakoli A, et al.. "Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1." Nanomedicine, vol. 13, no. 21, 2018, pp. -.
APA	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, Moghoofei M, Farahmand M, Javanmard D, Monavari SH (2018). Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1. Nanomedicine, 13(21), -.
Chicago	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, Moghoofei M, Farahmand M, Javanmard D, Monavari SH. "Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1." Nanomedicine 13, no. 21 (2018): -.
Harvard	Tavakoli A et al. (2018) 'Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1', Nanomedicine, 13(21), pp. -.
Vancouver	Tavakoli A, Ataeipirkooh A, Mm Sadeghi G, Bokharaeisalim F, Sahrapour P, Kiani SJ, et al.. Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1. Nanomedicine. 2018;13(21):-.
BibTex	@article{ author = {Tavakoli A and Ataeipirkooh A and Mm Sadeghi G and Bokharaeisalim F and Sahrapour P and Kiani SJ and Moghoofei M and Farahmand M and Javanmard D and Monavari SH}, title = {Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1}, journal = {Nanomedicine}, volume = {13}, number = {21}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Tavakoli A AU - Ataeipirkooh A AU - Mm Sadeghi G AU - Bokharaeisalim F AU - Sahrapour P AU - Kiani SJ AU - Moghoofei M AU - Farahmand M AU - Javanmard D AU - Monavari SH TI - Polyethylene Glycol-Coated Zinc Oxide Nanoparticle: An Efficient Nanoweapon to Fight Against Herpes Simplex Virus Type 1 JO - Nanomedicine VL - 13 IS - 21 SP - EP - PY - 2018 ER -

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