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Efficacy of Lacosamide in the Treatment of Non-Convulsive Seizure and Non-Convulsive Status Epilepticus in Septic Pa-Tients: A Narrative Review Publisher



Amini K1 ; Sahebnasagh A2 ; Mojtahedzadeh M3
Authors

Source: Frontiers in Emergency Medicine Published:2022


Abstract

Non-convulsive seizures (NCS) and non-convulsive status epilepticus (NCSE) are of the acute complications of patients admitted to the intensive care unit (ICU), which lead to increased mortality and morbidity. In these cases, immediate treatment with antiepileptic drugs (AEDs) is important to prevent further damage to the brain. AEDs are the first line of treatment, however, most of these medications have many side effects. In the recent years, significant advances have been made in this area and lacosamide is one of the therapeutic options. The intravenous formulation of this drug is most popular due to the lack of drug-drug interaction and properly designed studies which have been conducted in this field. In this review, the latest findings on the effect of lacosamide on acute non-convulsive and generalized-convulsive seizures (G-CS) are evaluated in critically ill patients admitted to the ICU. © 2022 Tehran University of Medical Sciences.
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