A Multivariate Analysis Model of Changes in Some Laboratory Parameters in Response to Covid-19, Diabetes, Gender, and Age Publisher Pubmed



Nabatchian F¹ ; Ashtiani M¹ ; Davoudi M¹ ; Teimourpour A² ; Davoudi N³
Source: Clinical Laboratory Published:2021

Abstract

Background: The aim of this study was to investigate changes in some laboratory parameters in response to four independent variables (COVID-19, diabetes, gender, and age) using univariate and multivariate analysis. Methods: We measured WBC (neutrophil and lymphocytes), RBC and platelet counts, and hemoglobin, lactate de-hydrogenase, C-reactive protein, IL-2, IL-4, and vitamin D3 levels in 30 hospitalized patients with severe COVID-19 and in 30 healthy people in terms of COVID-19. The population was divided into groups based on each of the variables of age, gender, COVID-19, and type 2 diabetes. Then they were subjected to univariate and multivariate analysis of logistic regression. Results: Based on CBC data, leukocytosis (in 70% of COVID-19 patients, 61.1% of diabetic patients, and 70.9 ± 18 years old), neutrophilia (in 73.3% of patients with COVID-19, 61.1% of diabetic patients, and 66 ± 18.6 years old), neutropenia (in 6.7% of patients with COVID-19, 27.8% of diabetic patients, and 33.6 ± 12.7 years old), lympho-cytosis (10% of patients with COVID-19, 33.3% of diabetic patients, and 35.4 ± 15.5 years old), and lymphocyto-penia (in 76.7% of patients with COVID-19, 66.7% of diabetic patients, and 67.1 ± 18.8 years old) were observed in the population. The elderly and those with COVID-19 had significant abnormal RBC and platelet counts. In-creased LDH and CRP levels and abnormal hemoglobin level were related to elderly, COVID-19, and diabetes conditions. Although the levels of IL-2 and -4 were significant in patients with COVID-19 and elderly; however, the changes were not significant in diabetic patients. Changes in serum vitamin D levels were not significant in any of the sub-groups. Conclusions: We showed that leukocytosis, neutrophilia, lymphocytopenia, abnormal counts of RBCs and plate-lets, the elevated levels of LDH and CRP, and abnormal hemoglobin levels in blood are considered as poor prog-nostic factors for COVID-19. © 2021 Verlag Klinisches Labor GmbH. All rights reserved.