Differential Expression of Cancer Stem Cell Markers Aldh1 and Cd133 in Various Lung Cancer Subtypes Publisher Pubmed



Roudi R^{1, 2, 3} ; Korourian A¹ ; Shariftabrizi A⁴ ; Madjd Z^{1, 2, 3}
Source: Cancer Investigation Published:2015

Abstract

Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression. Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. ALDH1 and CD133 had higher expression levels in the NSCLC compared to the SCLC. Over-expression of both ALDH1 and CD133 markers was exclusively found in SCC and ADC. Low level of ALDH1 expression was strongly correlated with poor differentiation in ADC cases. Thus, ALDH1high/CD133high phenotype can be considered as a CSC marker in some lung cancer subtypes. © 2015 Informa Healthcare USA, Inc.