Can Ki-67 Immunohistochemistry Marker Differentiate Mycosis Fungoides From Cutaneous Lichen Planus?



Hesari KK¹ ; Ramezanizoorab N² ; Ramezani M^{3, 4} ; Sadeghi M⁵ ; Rezaei M⁶ ; Khazaei S⁴
Source: Journal of Pakistan Association of Dermatologists Published:2022

Abstract

Objective The purpose of this study was to evaluate the immunohistochemical expression of Ki-67 marker in Mycosis Fungoides (MF) and Lichen Planus (LP) lesions. Methods This cross-sectional analytical study included patients undergoing skin biopsy with their first clinical and pathologic diagnosis of MF and cutaneous LP by Ki-67 immunohistochemistry (IHC). Sixty-two patients with cutaneous LP and MF were studied in two groups of 39 and 23 patients, respectively. Linear regression was used for the possible correlation between age and Ki-67 index (%) in both LP and MF patients. Results The results of this study found that Ki-67 was expressed in 100% of both MF and LP lesions, and no significant correlation was found between Ki-67 and either of the two types of diseases (p=0.606). The results of this study also showed that expression of Ki-67 marker was more than 25% in both types of diseases in 70% of the population, which seems not to be directly related to malignancy. Conclusion IHC with proliferative marker Ki-67 is not a valuable technique for differentiating cutaneous LP from MF lesions alone. © 2022 Pakistan Association of Dermatologists. All rights reserved.