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Sex Differences in Covid-19 Mortality Risk in Patients on Kidney Function Replacement Therapy Publisher Pubmed



Vart P1, 2 ; Duivenvoorden R3 ; Adema A4 ; Covic A5, 6 ; Finne P7 ; Braak NHT8 ; Laine K9 ; Noordzij M1 ; Schouten M10 ; Jager KJ11, 12 ; Gansevoort RT1 ; Van Der Net JB13 ; Essig M14 ; Du Bufvereijken PWG15 Show All Authors
Authors
  1. Vart P1, 2
  2. Duivenvoorden R3
  3. Adema A4
  4. Covic A5, 6
  5. Finne P7
  6. Braak NHT8
  7. Laine K9
  8. Noordzij M1
  9. Schouten M10
  10. Jager KJ11, 12
  11. Gansevoort RT1
  12. Van Der Net JB13
  13. Essig M14
  14. Du Bufvereijken PWG15
  15. Van Ginneken B15
  16. Maas N15
  17. Van Jaarsveld BC16
  18. Bemelman FJ16
  19. Klingenbergsalahova F16
  20. Heenanvos F16
  21. Vervloet MG16
  22. Nurmohamed A16
  23. Vogt L16
  24. Abramowicz D17
  25. Verhofstede S17
  26. Maoujoud O18
  27. Malfait T19
  28. Fialova J20
  29. Melilli E21
  30. Fava A21
  31. Cruzado JM21
  32. Perez NM21
  33. Lips J22
  34. Krepel H23
  35. Adilovic H24
  36. Radulescu D25, 26
  37. Hengst M27
  38. Konings C27
  39. Rydzewski A28
  40. Braconnier P29
  41. Weis D29
  42. Gellert R30
  43. Oliveira J31
  44. Alferes DG32
  45. Zakharova EV33
  46. Ambuhl PM34
  47. Guidotti R34
  48. Walker A34
  49. Lepeytre F35
  50. Rabate C35
  51. Rostoker G35
  52. Marques S36
  53. Azasevac T37
  54. Majstorovic GS37
  55. Katicic D38
  56. Ten Dam M39
  57. Kruger T40
  58. Brzosko S41
  59. Liakopoulos V42
  60. Zanen AL43
  61. Logtenberg SJJ44
  62. Fricke L45
  63. Kuryata O46
  64. Slebe JJP47
  65. Elhafeez SA48
  66. Kemlin D49
  67. Van De Wetering J50
  68. Reinders MEJ50
  69. Hesselink DA50
  70. Kalvan Gestel J50
  71. Eiselt J51
  72. Kielberger L51
  73. Elwakil HS52
  74. Verhoeven M53
  75. Logan I54
  76. Canal C55
  77. Facundo C55
  78. Ramos AM56
  79. Debskaslizien A57
  80. Veldhuizen NMH58
  81. Tigka E59
  82. Konsta MAP60
  83. Panagoutsos S61
  84. Mallamaci F62
  85. Postorino A62
  86. Cambareri F62
  87. Matceac I5, 6
  88. Nistor I5, 6
  89. Groeneveld JHM63
  90. Jousma J63
  91. Van Buren M64
  92. Diekmann F65
  93. Oppenheimer F65
  94. Blasco M65
  95. Pereira TA66
  96. Ariascabrales C68
  97. Crespo M68
  98. Llinasmallol L68
  99. Buxeda A68
  100. Tarrega CB68
  101. Redondopachon D68
  102. Jimenez MDA68
  103. Mendozavalderrey A68
  104. Martins AC69
  105. Mateus C69
  106. Alvila G69
  107. Laranjinha I69
  108. Hofstra JM70
  109. Siezenga MA70
  110. Franco A71
  111. Arroyo D72
  112. Castellano S72
  113. Rodriguezferrero ML72
  114. Manzanos SB73
  115. Barrios RHS74
  116. Lemahieu W75
  117. Bartelet K76
  118. Dirim AB77
  119. Demir E77
  120. Sever MS77
  121. Turkmen A77
  122. Safak S77
  123. Hollander DAMJ78
  124. Buttner S79
  125. De Vries APJ80
  126. Meziyerh S80
  127. Van Der Helm D80
  128. Mallat M80
  129. Bouwsma H80
  130. Sridharan S81
  131. Petruliene K82
  132. Maloney SR83
  133. Verberk I84
  134. Van Der Sande FM85
  135. Christiaans MHL85
  136. Hemmelder MH85
  137. Mohankumar N86
  138. Di Luca M87
  139. Tuglular SZ88
  140. Kramer AB89
  141. Beerenhout C90
  142. Luik PT91
  143. Kerschbaum J92
  144. Tiefenthaler M92
  145. Watschinger B93
  146. Stepanov VA94
  147. Zulkarnaev AB94
  148. Turkmen K95
  149. Gandolfini I96
  150. Maggiore U96
  151. Fliedner A97
  152. Asberg A98
  153. Mjoen G98
  154. Miyasato H99
  155. De Fijter CWH100
  156. Mongera N101
  157. Pini S102
  158. De Biase C103
  159. Kerckhoffs A103
  160. Van De Logt AE103
  161. Maas R103
  162. Hilbrands LB103
  163. Lebedeva O104
  164. Lopez V105
  165. Reichert LJM106
  166. Verhave J106
  167. Titov D107
  168. Parshina EV108
  169. Zanoli L109
  170. Marcantoni C109
  171. Van Kempen G110
  172. Van Gilsverrij LEA111
  173. Harty JC112
  174. Meurs M113
  175. Myslak M114
  176. Battaglia Y115
  177. Lentini P116
  178. Den Deurwaarder E117
  179. Stendahl M118
  180. Rahimzadeh H119
  181. Rychlik I120
  182. Cabezasreina CJ121
  183. Roca AM121
  184. Nauta F122
  185. Sahin I123
  186. Goffin E124
  187. Kanaan N124
  188. Labriola L124
  189. Devresse A124
  190. Diazmareque A125
  191. Coca A126
  192. De Arriba G127
  193. Meijers BKI128
  194. Naesens M128
  195. Kuypers D128
  196. Desschans B128
  197. Tonnerlier A129
  198. Wissing KM129
  199. Dedinska I130
  200. Pessolano G131
  201. Malik S132
  202. Dounousi E133
  203. Papachristou E134
  204. Berger SP135
  205. Sanders JSF135
  206. Franssen CFM135
  207. Ozyilmaz A135
  208. Ponikvar JB136
  209. Pernat AM136
  210. Kovac D136
  211. Arnol M136
  212. Ekart R137
  213. Abrahams AC138
  214. Molenaar FM138
  215. Van Zuilen AD138
  216. Meijvis SCA138
  217. Dolmans H138
  218. Tantisattamo E139
  219. Esposito P140
  220. Krzesinski JM141
  221. Barahira JD141
  222. Gallieni M142
  223. Martinmoreno PL143
  224. Guglielmetti G144
  225. Guzzo G145
  226. Toapanta N146
  227. Soler MJ146
  228. Luik AJ147
  229. Van Kuijk WHM147
  230. Stikkelbroeck LWH147
  231. Hermans MMH147
  232. Rimsevicius L148
  233. Righetti M149
  234. Islam M150

Source: Scientific Reports Published:2022


Abstract

In the general population with COVID-19, the male sex is an established risk factor for mortality, in part due to a more robust immune response to COVID-19 in women. Because patients on kidney function replacement therapy (KFRT) have an impaired immune response, especially kidney transplant recipients due to their use of immunosuppressants, we examined whether the male sex is still a risk factor for mortality among patients on KFRT with COVID-19. From the European Renal Association COVID-19 Database (ERACODA), we examined patients on KFRT with COVID-19 who presented between February 1st, 2020, and April 30th, 2021. 1204 kidney transplant recipients (male 62.0%, mean age 56.4 years) and 3206 dialysis patients (male 61.8%, mean age 67.7 years) were examined. Three-month mortality in kidney transplant recipients was 16.9% in males and 18.6% in females (p = 0.31) and in dialysis patients 27.1% in males and 21.9% in females (p = 0.001). The adjusted HR for the risk of 3-month mortality in males (vs females) was 0.89 (95% CI 65, 1.23, p = 0.49) in kidney transplant recipients and 1.33 (95% CI 1.13, 1.56, p = 0.001) in dialysis patients (pinteraction = 0.02). In a fully adjusted model, the aHR for the risk of 3-month mortality in kidney transplant recipients (vs. dialysis patients) was 1.39 (95% CI 1.02, 1.89, p = 0.04) in males and 2.04 (95% CI 1.40, 2.97, p < 0.001) in females (pinteraction = 0.02). In patients on KFRT with COVID-19, the male sex is not a risk factor for mortality among kidney transplant recipients but remains a risk factor among dialysis patients. The use of immunosuppressants in kidney transplant recipients, among other factors, may have narrowed the difference in the immune response to COVID-19 between men and women, and therefore reduced the sex difference in COVID-19 mortality risk. © 2022, The Author(s).
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