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Fibrinogen Dysregulation Is a Prominent Process in Fatal Conditions of Covid-19 Infection; a Proteomic Analysis Publisher



Rezaeitavirani M1 ; Nejad MR2 ; Arjmand B3 ; Tavirani SR1 ; Razzaghi M4 ; Mansouri V1
Authors

Source: Archives of Academic Emergency Medicine Published:2021


Abstract

Introduction: Molecular pathophysiology of COVID-19 is not completely known. Expression changes in patients’ plasma proteins have revealed new information about the disease. Introducing the key targeted plasma protein in fatal conditions of COVID-19 infection is the aim of this study. Methods: Significant differentially expressed proteins (DEPs) in the plasma of cases with a fatal condition of COVID-19 were extracted from an original article. These proteins were included in a network via STRING database along with 100 first neighbor proteins to determine central nodes of the network for analyzing. Results: Queried and added proteins were included in a scale free network. Three hub nodes were identified as critical target proteins. The top queried hub proteins were chains of fibrinogen; Fibrinogen Alpha chain (FGA), Fibrinogen gamma chain (FGG), and Fibrinogen beta chain (FGB), which are related to the coagulation process. Conclusion: It seems that fibrinogen dysregulation has a deep impact on the fatality of COVID-19 infection. © 2021. All Rights Reserved.
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