Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana

Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana Publisher Pubmed

Gohari AR¹ ; Mosaddegh M² ; Naghibi F² ; Eslamitehrani B² ; Pirani A² ; Hamzeloomoghadam M³ ; Read RW⁴

Source: Anais da Academia Brasileira de Ciencias Published:2015

Abstract

Inula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1p,5a,7oH-4p-hydroxy-guai-9(10),11(13)-dien-12,8a-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1p,5a,7aH-4p-hydroxy-guai-9(10),11(13)-dien-12,8a-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) |ig/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies. © 2015, Academia Brasileira de Ciencias. All rights reserved.

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Style	Citing Format
MLA	Gohari AR, et al.. "Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana." Anais da Academia Brasileira de Ciencias, vol. 87, no. 2, 2015, pp. 777-785.
APA	Gohari AR, Mosaddegh M, Naghibi F, Eslamitehrani B, Pirani A, Hamzeloomoghadam M, Read RW (2015). Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana. Anais da Academia Brasileira de Ciencias, 87(2), 777-785.
Chicago	Gohari AR, Mosaddegh M, Naghibi F, Eslamitehrani B, Pirani A, Hamzeloomoghadam M, Read RW. "Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana." Anais da Academia Brasileira de Ciencias 87, no. 2 (2015): 777-785.
Harvard	Gohari AR et al. (2015) 'Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana', Anais da Academia Brasileira de Ciencias, 87(2), pp. 777-785.
Vancouver	Gohari AR, Mosaddegh M, Naghibi F, Eslamitehrani B, Pirani A, Hamzeloomoghadam M, et al.. Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana. Anais da Academia Brasileira de Ciencias. 2015;87(2):777-785.
BibTex	@article{ author = {Gohari AR and Mosaddegh M and Naghibi F and Eslamitehrani B and Pirani A and Hamzeloomoghadam M and Read RW}, title = {Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana}, journal = {Anais da Academia Brasileira de Ciencias}, volume = {87}, number = {2}, pages = {777-785}, year = {2015} }
RIS	TY - JOUR AU - Gohari AR AU - Mosaddegh M AU - Naghibi F AU - Eslamitehrani B AU - Pirani A AU - Hamzeloomoghadam M AU - Read RW TI - Cytotoxic Sesquiterpene Lactones From the Aerial Parts of Inula Aucheriana JO - Anais da Academia Brasileira de Ciencias VL - 87 IS - 2 SP - 777 EP - 785 PY - 2015 ER -

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