Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs Publisher



Alizadeh BH1 ; Emami S3 ; Dehghan G4 ; Foroumadi A5 ; Shafiee A5
Authors

Source: Journal of Heterocyclic Chemistry Published:2017


Abstract

A series of aryltetralin lignans 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized as cytotoxic isodeoxypodophyllotoxin analogs. The title compounds 7a, 7b, 7c, 7d, 7e, 7f, 7g, 7h, 7i, 7j, 7k, 7l were synthesized from the reaction of (+)-(R)-4-[benzo(d)(1,3)dioxol-5-ylmethyl]-dihydrofuran-2-(3H)-one with different arylaldehydes to afford benzyl alcohol analogs and subsequent cyclization with trifluoroacetic acid in dichromethane. The preliminary screening of the compounds against viability of blood cancer human cell line K562 revealed that compounds 7d, 7e, and 7f had higher inhibitory activity at 10 µg/mL concentration compared with etoposide as reference drug. © 2016 Wiley Periodicals, Inc.
Related Docs
View other Related Docs
1. Synthesis and Anticancer Activity of N -Substituted 2-Arylquinazolinones Bearing Trans -Stilbene Scaffold, European Journal of Medicinal Chemistry (2015)
2. Synthesis of Some Novel Pyrano[2,3-F]Chromenone Derivatives, Journal of the Iranian Chemical Society (2015)
3. New Benzothiazole-Indole-1,2,3-Triazole-N-Phenylacetamide Derivatives As Cytotoxic Agents: Design, Synthesis, and in Vitro Cytotoxic Evaluations, Journal of Molecular Structure (2025)
Experts (# of related papers)
View all Related Experts
Alireza Foroumadi (10)
Mohammad Mahdavi (9)
Other Related Docs
4. Synthesis and Cytotoxic Activity of Novel Poly-Substituted Imidazo[2,1-C][1,2,4]Triazin-6-Amines, Molecular Diversity (2015)
5. Synthesis and Cytotoxic Activity of Some Novel Dihyrobenzo[H]Pyrano [3,2-C]Chromene Derivatives, Journal of Heterocyclic Chemistry (2015)
6. Synthesis and Biological Evaluation of 12-Aryl-11-Hydroxy-5,6-Dihydropyrrolo[2″,1″:3′,4′]Pyrazino[1′,2′:1,5]Pyrrolo[2,3-D]Pyridazine-8(9H)-One Derivatives As Potential Cytotoxic Agents, ACS Omega (2023)
7. Novel Quinazolin-4(3H)-One Linked to 1,2,3-Triazoles: Synthesis and Anticancer Activity, Chemical Biology and Drug Design (2018)
8. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 3,4-Diaryl-5-(4-Pyridinyl)-1,2,4-Oxadiazole, Medicinal Chemistry (2016)
9. Design, Synthesis, and Molecular Docking Studies of Diphenylquinoxaline-6-Carbohydrazide Hybrids As Potent Α-Glucosidase Inhibitors, BMC Chemistry (2022)
10. Kopetdaghinanes, Pro-Apoptotic Hemiacetialic Cyclomyrsinanes From Euphorbia Kopetdaghi, Fitoterapia (2020)
11. Apoptotic Effects of Two Cox-2 Inhibitors on Breast Adenocarcinoma Cells Through Cox-2 Independent Pathway, Journal of Cellular Biochemistry (2015)
12. An Experimental and Theoretical Approach of a Novel Phosphoramide Containing Naphthoquinone With Potential Cytotoxic and Apoptosis-Inducing Ability, Journal of Molecular Structure (2025)
13. Histone Deacetylase Inhibitory and Cytotoxic Activities of the Constituents From the Roots of Sophora Pachycarpa, Iranian Journal of Pharmaceutical Research (2020)
14. Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives As Anticancer Agents, Letters in Drug Design and Discovery (2017)
15. A Short Synthesis of 7-Amino Alkoxy Homoisoflavonoides, RSC Advances (2017)
16. Synthesis and Cytotoxicity of Novel Thioxo-Quinazolino[3,4-A]Quinazolinones, Turkish Journal of Chemistry (2017)
17. Design, Synthesis, Docking Studies, and Biological Activity of Novel Analogs of Cyclophosphamide As Potential Anticancer Agents, Current Medicinal Chemistry (2025)
18. Preparation of Some Novel Imidazopyridine Derivatives of Indole As Anticancer Agents: One-Pot Multicomponent Synthesis, Biological Evaluation and Docking Studies, Research on Chemical Intermediates (2019)
19. Synthesis, Molecular Docking, and Biological Evaluation of Pyridin-3-Yl-Pyrimidin-2-Yl-Triazole Derivatives As Anti-Cancer Agents, Polycyclic Aromatic Compounds (2024)
20. Novel Quinazolines Bearing 1,3,4-Thiadiazole-Aryl Urea Derivative As Anticancer Agents: Design, Synthesis, Molecular Docking, Dft and Bioactivity Evaluations, BMC Chemistry (2024)