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Development of Lanthanide-Based “All in One” Theranostic Nanoplatforms for Tme-Reinforced T1-Weighted Mri/Ct Bimodal Imaging Publisher



Sabaghi V1 ; Rashidiranjbar P1 ; Davar F2 ; Sharifpaghaleh E3, 4
Authors

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

The design and development of lanthanide-based theranostic nanoplatforms, owing to unique physiochemical properties have attracted significant interest in enhancing the diagnostic and therapeutic efficiency against cancer. In this study, hollow Nd-doped Gd2O3 (H-NdxGd2-xO3) nanostructures were synthesized through the scarified template strategy. Qualitative and quantitative X-ray analysis confirmed the substitution of Nd3+ ions by Gd3+ ions in the cubic structure of pristine H–Gd2O3 nanostructure. Polyethylene glycol (PEG) successfully decorated the surface of the as-synthesized nanostructure to reduce the inherent toxicity. H-NdxGd2-xO3@PEG nanoplatforms showed a significant DOX adsorption capacity (149.5 mg/g). Biocompatible H-NdxGd2-xO3@PEG nanoplatforms showed a considerable response to the simulated tumor microenvironment (TME) of cancer. The characteristic features of simulated TME of cancer not only enhance the drug release efficiency (72%), but also reinforced the T1-weighted MRI signal (19.33 mM−1. S−1), and CT signal (247 HU). © 2023 Elsevier B.V.
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