Autoimmunity Roots of the Thrombotic Events After Covid-19 Vaccination Publisher Pubmed



Elrashdy F¹ ; Tambuwala MM² ; Hassan SS³ ; Adadi P⁴ ; Seyran M⁵ ; Abd Elaziz TM^{6, 7} ; Rezaei N^{8, 9} ; Lal A¹⁰ ; Aljabali AAA¹¹ ; Kandimalla R^{12, 13} ; Bazan NG¹⁴ ; Azad GK¹⁵ ; Sherchan SP¹⁶ ; Choudhury PP¹⁷ Show All Authors
Source: Autoimmunity Reviews Published:2021

Abstract

Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of available vaccines were proven, a small number of individuals who received anti-SARS-CoV-2 vaccines developed a prothrombotic syndrome. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by the adenoviral vector-based vaccine, whereas lipid nanoparticle-mRNA-based vaccines can induce rare cases of deep vein thrombosis (DVT). Although the main pathogenic mechanisms behind this rare phenomenon have not yet been identified, both host and vaccine factors might be involved, with pathology at least in part being related to the vaccine-triggered autoimmune reaction. In this review, we are considering some aspects related to pathogenesis, major risk factors, as well as peculiarities of diagnosis and treatment of this rare condition. © 2021 Elsevier B.V.