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Antibody-Mediated Rejection of Kidney Allografts Following Covid-19: A Report of Two Cases Publisher Pubmed



Fazeli SA1, 2, 3 ; Takyar M4 ; Parvin M5 ; Haririan A6 ; Alirezaei A1
Authors

Source: Iranian Journal of Kidney Diseases Published:2022


Abstract

Increased risk of graft rejection could be the consequence of COVID-19 in kidney transplant recipients (KTRs). We report two cases of kidney transplant (KT) with stable graft function who experienced antibody-mediated rejection (ABMR) following recovery from COVID-19. It seems that reduced immunosuppression during the acute illness, is the main explanation for post-COVID-19 ABMR. However, the inflammatory state associated with COVID-19, as well as direct cytopathic effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can predispose the kidney allograft to rejection. There is no definite guideline for the modification of immunosuppressives during COVID-19 in kidney transplant recipients. However, re-institution of full-dose immunosuppressives soon after recovery from COVID-19 and frequent outpatient follow-up visits are recommended. © 2022, Iranian Society of Nephrology. All rights reserved.
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