The Minimal Clinically Important Difference of Two Multifaceted Fatigue Evaluation Questionnaires in Chronic Stroke Publisher Pubmed



Fallah S¹ ; Parnain Z² ; Taghaviazarsharabiani P³ ; Cheraghifard M⁴ ; Vasaghigharamaleki B⁵ ; Roohiazizi M⁵ ; Hashemi M⁶ ; Yousefi M² ; Joghataei MT^{7, 8} ; Taghizadeh G⁹
Source: Topics in Stroke Rehabilitation Published:2025

Abstract

Purpose: This research sought to ascertain the Minimal Clinically Important Difference (MCID) and Robust Clinically Important Difference (RCID) of the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF) and Chalder Fatigue Questionnaire-11 (CFQ-11) as two important concepts for the clinical interpretation of the results in chronic post-stroke population. Methods: A total of 128 subjects with chronic post-stroke completed the MFSI-SF and CFQ-11 before and after six weeks of intervention. The MCIDs were derived using both anchor- and distribution-based methods; however, only anchor-based methods were used to estimate RCIDs. Results: Anchor-based MCIDs for MFSI-SF and CFQ-11 were in the range of −5 to −6.28 and −2 to −4.56, respectively. Distribution-based MCIDs in MFSI-SF and CFQ-11 were calculated in the range of −4.17 to −24.05 and −1.72 to −7.68, respectively. RCID ranges of −10 to −15 were obtained for the MFSI-SF and −6 to −7.33 for the CFQ-11. Conclusion: These findings may have implications for clinical experts in the clinical interpretation of fatigue changes observed in MFSI-SF and CFQ-11 in individuals with chronic stroke. © 2024 Taylor & Francis Group, LLC.