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Synthesis and in Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives Publisher



Najafi Z1 ; Mahdavi M2 ; Safavi M3 ; Saeedi M2 ; Alinezhad H4 ; Pordeli M5 ; Kabudanian Ardestani S5 ; Shafiee A2 ; Foroumadi A2 ; Akbarzadeh T1, 6
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Source: Journal of Heterocyclic Chemistry Published:2015


Abstract

New derivatives of triazole-isoxazole were synthesized through a four-step reaction starting from various ethyl 4-aryl-2,4-dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF-7 and T-47D). © 2014 HeteroCorporation.
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