Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives

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Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives Publisher

Firoozpour L¹ ; Kazemzadeh Arasi F² ; Toolabi M³ ; Moghimi S¹ ; Armandeh M⁴ ; Salmani F⁵ ; Pakrad R⁵ ; Firuzpour H⁵ ; Ghasemi Dogaheh M⁶ ; Ebrahimi SES² ; Hme Ketabforoosh S⁷ ; Karima S⁵ ; Foroumadi A^{1, 2}

Source: Medicinal Chemistry Research Published:2023

Abstract

In this paper, pyridazin derivatives containing different thiobenzyl moieties were synthesized and screened for their inhibitory activities against rat intestinal α-glucosidase enzyme. The final products were easily obtained without the need to harsh purification steps. The in vitro results revealed that all the synthesized compounds were more potent (IC50s = 26.3–148.9 μM) than the clinically used drug, acarbose. The kinetic study revealed the competitive inhibition behavior of compound 5m (Ki = −56 μM). Docking studies showed imperative interactions such as hydrogen bonding, Pi-Pi T-shaped, and Pi-anion interactions confirming the observed activity. The RMSD value was determined less than 3 A and validated the study. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Style	Citing Format
MLA	Firoozpour L, et al.. "Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives." Medicinal Chemistry Research, vol. 32, no. 4, 2023, pp. 713-722.
APA	Firoozpour L, Kazemzadeh Arasi F, Toolabi M, Moghimi S, Armandeh M, Salmani F, Pakrad R, Firuzpour H, Ghasemi Dogaheh M, Ebrahimi SES, Hme Ketabforoosh S, Karima S, Foroumadi A (2023). Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives. Medicinal Chemistry Research, 32(4), 713-722.
Chicago	Firoozpour L, Kazemzadeh Arasi F, Toolabi M, Moghimi S, Armandeh M, Salmani F, Pakrad R, et al.. "Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives." Medicinal Chemistry Research 32, no. 4 (2023): 713-722.
Harvard	Firoozpour L et al. (2023) 'Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives', Medicinal Chemistry Research, 32(4), pp. 713-722.
Vancouver	Firoozpour L, Kazemzadeh Arasi F, Toolabi M, Moghimi S, Armandeh M, Salmani F, et al.. Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives. Medicinal Chemistry Research. 2023;32(4):713-722.
BibTex	@article{ author = {Firoozpour L and Kazemzadeh Arasi F and Toolabi M and Moghimi S and Armandeh M and Salmani F and Pakrad R and Firuzpour H and Ghasemi Dogaheh M and Ebrahimi SES and Hme Ketabforoosh S and Karima S and Foroumadi A}, title = {Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives}, journal = {Medicinal Chemistry Research}, volume = {32}, number = {4}, pages = {713-722}, year = {2023} }
RIS	TY - JOUR AU - Firoozpour L AU - Kazemzadeh Arasi F AU - Toolabi M AU - Moghimi S AU - Armandeh M AU - Salmani F AU - Pakrad R AU - Firuzpour H AU - Ghasemi Dogaheh M AU - Ebrahimi SES AU - Hme Ketabforoosh S AU - Karima S AU - Foroumadi A TI - Design, Synthesis and Α-Glucosidase Inhibition Study of Novel Pyridazin-Based Derivatives JO - Medicinal Chemistry Research VL - 32 IS - 4 SP - 713 EP - 722 PY - 2023 ER -

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