The Role of Small Extracellular Vesicles Derived From Glial Cells in the Central Nervous System Under Both Normal and Pathological Conditions Publisher Pubmed

Summary: Glial cells' bubble mail? Small EVs ferry miRNAs, modulating neuroinflammation via astrocytes/microglia. Review: Key in disease progression—therapy target? Polarizes cells. #Neuroscience #EVs

Negah SS⁴ ; Moradi HR² ; Forouzanfar F^{1, 3} ; Sahraian MA⁴ ; Faraji M²
Source: Neurochemical Research Published:2025

Abstract

In recent decades, researchers and clinicians have increasingly focused on glial cell function. One of the primary mechanisms influencing these functions is through extracellular vesicles (EVs), membrane-bound particles released by cells that are essential for intercellular communication. EVs can be broadly categorized into four main types based on their size, origin, and biogenesis: large EVs, small EVs (sEVs), autophagic EVs, and apoptotic bodies. Small EVs (sEVs) are involved in various physiological and pathological processes such as immune responses, angiogenesis, and cellular communication, primarily by transferring proteins, lipids, and nucleic acids to recipient cells. Interactions among glial cells mediated by small EVs can significantly modulate cell polarization and influence glial behavior through miRNA transfer. This communication, facilitated by small EVs in glial cells, is crucial for neuroinflammation, immune responses, and disease progression. This comprehensive review focuses on driven by glial small EVs, highlighting their roles in transporting biomolecules and modulating the functions of recipient cells. Furthermore, we provide an in-depth overview of the specific contributions of small EVs derived from three principal types of glial cells: oligodendrocytes, astrocytes, and microglia. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.