Lupus Erythematosus and Chronic Granulomatous Disease: Report of Four Iranian Patients With Ar-Cgd and One Xl-Cgd Publisher Pubmed



Maddah M¹ ; Fazlollahi MR¹ ; Shiari R² ; Shahram F³ ; Mamishi S⁴ ; Babaie D⁵ ; Monajemzadeh M⁶ ; Sotoudeh S⁷ ; Hamidieh AA⁸ ; Badalzadeh M¹ ; Tajik S¹ ; Sedighipour L¹ ; Pourpak Z¹
Source: Iranian Journal of Allergy# Asthma and Immunology Published:2019

Abstract

Chronic granulomatous disease (CGD) is a rare genetic disorder of neutrophil activity, resulting in increased rate of recurrent infections with catalase-positive bacteria and fungi, as well as various autoimmune diseases such as sarcoidosis, rheumatoid arthritis, and discoid and/or systemic lupus erythematosus. Few reports have reported lupus erythematosus (LE) in patients with X-linked CGD (XL-CGD) and carriers, and very few in autosomal recessive CGD (AR-CGD). Here, we present 5 patients with CGD developing LE at different ages to emphasize on the importance of appropriate follow-up and treatment in patients with CGD with clinical signs and symptoms of autoimmune diseases and even in those with negative serologic results. © August 2019, Iran J Allergy Asthma Immunol.