Serum Levels of C1q/Tnf-Related Protein-3 in Inflammatory Bowel Disease Patients and Its Inverse Association With Inflammatory Cytokines and Insulin Resistance Publisher Pubmed



Mohamadinarab M¹ ; Ahmadi R² ; Gholamrezayi A³ ; Rahvar F⁴ ; Naghdalipour M⁵ ; Setayesh L⁶ ; Moradi N⁷ ; Fadaei R⁸ ; Chamani E⁹ ; Tavakoli T^{9, 10} ; Esteghamati A⁵
Source: IUBMB Life Published:2020

Abstract

Ulcerative colitis (UC) and Crohn's disease (CD) are two major forms of inflammatory bowel disease (IBD), which is an inflammatory disease. Studies have shown that adipose tissue and inflammation play important roles in the pathogenesis of IBD. C1q/TNF-related protein-3 (CTRP3) is a newly discovered adipokine playing a substantial role during inflammatory process, and for the first time in the present study, serum levels of this adipokine were measured in the UC and CD patients. This case–control study included 70 control, 50 UC, and 50 CD patients who were diagnosed by standard criteria. Serum levels of adiponectin, IL-6, TNF-α, TGF-β, and CTRP3 were evaluated using ELISA kits. Serum levels of IL-6, TNF-α, and TGF-β elevated in the UC and CD patients compared with the controls while adiponectin and CTRP3 diminished in the patient's groups compared with the control. Furthermore, decrease in CTRP3 serum levels was associated with the risk of UC and CD diseases. Moreover, CTRP3 indicated negative correlation with BMI, FBS, insulin, homeostasis model assessment of insulin resistance, IL-6, TNF-α, and TGF-β and also a positive correlation with adiponectin in both the UC and CD patients. For the first time, the present study demonstrated lower levels of CTRP3 in the UC and CD patients. Decreased serum levels of CTRP3 and its inverse relationship with inflammatory cytokines and TGF-β levels suggested a possible role for CTRP3 in the pathogenesis of UC and CD diseases. © 2020 International Union of Biochemistry and Molecular Biology